622855-60-1
Chemical Structure
DB07006
- CAS No.: 622855-60-1
- Formula:C24H20N2O5
- Molecular Weight:416.43
IUPAC Name: 9-hydroxy-6-(3-hydroxypropyl)-4-(2-methoxyphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
InChIKey: AOGOZJCRIFBTTN-UHFFFAOYSA-N
SMILES: O=C1NC(C2=C(C3=C(N4CCCO)C=CC(O)=C3)C4=CC(C5=C(OC)C=CC=C5)=C21)=O
Biological Activity: DB07006 (compound 18) is a potent, ATP-cpmpetitive dual inhibitor of Wee1 (IC50 = 0.030 μM) and Chk1 checkpoint kinases (IC50 = 0.018 μM). DB07006 demonstrates effective abrogation of the G2/M checkpoint in combination with DNA-damaging agents in cellular models. DB07006 can be used for cancer research[1].
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DB07006 | DB07006 (compound 18) is a potent, ATP-cpmpetitive dual inhibitor of Wee1 (IC50 = 0.030 μM) and Chk1 checkpoint kinases (IC50 = 0.018 μM). DB07006 demonstrates effective abrogation of the G2/M checkpoint in combination with DNA-damaging agents in cellular models. DB07006 can be used for cancer research. | |||||||||||||||||||||
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Keywords
