667427-75-0
Chemical Structure
TRPC6-PAM-C20
- CAS No.: 667427-75-0
- Formula:C22H21NO4
- Molecular Weight:363.41
IUPAC Name: 3-(6,7-dimethoxy-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-2H-chromen-2-one
InChIKey: SNICUMZYPOCXCO-UHFFFAOYSA-N
SMILES: O=C1C(C2=NC(C)(C)CC3=C2C=C(OC)C(OC)=C3)=CC4=CC=CC=C4O1
Biological Activity: TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+ concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals[1].
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TRPC6-PAM-C20 | 99.78% | TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+ concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals. | ||||||||||||||||||||
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Keywords
