69391-08-8
Chemical Structure
Allantoxanamide
- CAS No.: 69391-08-8
- Formula:C4H4N4O3
- Molecular Weight:156.10
IUPAC Name: 4-hydroxy-6-oxo-1,6-dihydro-1,3,5-triazine-2-carboxamide
InChIKey: HJXJVORILFDIOT-UHFFFAOYSA-N
SMILES: O=C(C(N1)=NC(O)=NC1=O)N
Biological Activity: Allantoxanamide is a uricase inhibitor that induces hyperuricemia by inhibiting uric acid degradation. Allantoxanamide inhibits uricase activity in vitro with an IC50 of approximately 0.9 μM and increases serum uric acid levels in rats. Allantoxanamide can be used for the study of hyperuricemia, uric acid metabolism, hyperuricemia-associated nephropathy, and related metabolic research[1][2][3][4].
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Allantoxanamide | 98.79% | Allantoxanamide is a uricase inhibitor that induces hyperuricemia by inhibiting uric acid degradation. Allantoxanamide inhibits uricase activity in vitro with an IC50 of approximately 0.9 μM and increases serum uric acid levels in rats. Allantoxanamide can be used for the study of hyperuricemia, uric acid metabolism, hyperuricemia-associated nephropathy, and related metabolic research. | ||||||||||||||||||||
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- [1]. Johnson WJ, Chartrand A. Allantoxanamide: a potent new uricase inhibitor in vivo. Life Sci. 1978 Nov 27;23(22):2239-44. [Content Brief]
- [2]. Chen W, et al. Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo. Metabolism. 2014;63(1). doi:10.1016/j.metabol.2013.09.018.
- [3]. Yonetani Y, et al. Decreasing Effect of Allantoxanamide, a Hyperuricemic Agent on Renal Functions in Rats. Japan J Pharmacol. 1987;45:37-43.
- [4]. Barrera CM, et al. Hyperuricemia and Locomotor Activity in Developing Rats. Pharmacology Biochemistry & Behavior. 1989;33(2):367-369.
Keywords
