725233-55-6
725233-55-6
Chemical Structure
ISS610
- CAS No.: 725233-55-6
- Formula:C23H26N3O8P
- Molecular Weight:503.44
IUPAC Name: ((S)-2-(4-cyanobenzamido)-3-(4-(phosphonooxy)phenyl)propanoyl)-L-leucine
InChIKey: HXSAWUQKNZJUNW-PMACEKPBSA-N
SMILES: O=P(O)(O)OC(C=C1)=CC=C1C[C@@H](C(N[C@H](C(O)=O)CC(C)C)=O)NC(C2=CC=C(C=C2)C#N)=O
Biological Activity: ISS610 is a selective Stat3 inhibitor with an IC50 of 42 μM. ISS610 induces Apoptosis. ISS610 can be used in research related to breast cancer and non-small cell lung cancer[1][2].
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ISS610 | ISS610 is a selective Stat3 inhibitor with an IC50 of 42 μM. ISS610 induces Apoptosis. ISS610 can be used in research related to breast cancer and non-small cell lung cancer. | |||||||||||||||||||||
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References
- [1]. Turkson J, et al. A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. The Journal of biological chemistry. 2005 Sep 23;280(38):32979-88.
- [2]. Lavecchia A, et al. STAT-3 inhibitors: state of the art and new horizons for cancer treatment. Current medicinal chemistry. 2011;18(16):2359-75.
