757950-09-7
757950-09-7
Chemical Structure
Raseglurant
Synonym(s): ADX-10059
- CAS No.: 757950-09-7
- Formula:C15H13FN2
- Molecular Weight:240.28
IUPAC Name: 2-((3-fluorophenyl)ethynyl)-4,6-dimethylpyridin-3-amine
InChIKey: MEDCLNYIYBERKO-UHFFFAOYSA-N
SMILES: NC1=C(C)C=C(C)N=C1C#CC2=CC=CC(F)=C2
Biological Activity: Raseglurant (ADX-10059) is a mGlu5 receptor negative allosteric modulator. Raseglurant is effective against migraine. Raseglurant reduces the Haloperidol (HY-14538)-induced catalepsy in mice[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Raseglurant | 99.65% | Raseglurant (ADX-10059) is a mGlu5 receptor negative allosteric modulator. Raseglurant is effective against migraine. Raseglurant reduces the Haloperidol (HY-14538)-induced catalepsy in mice. | ||||||||||||||||||||
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References
- [1]. Romero-Fernandez W, et al. The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for Parkinson's Disease. Mol Neurobiol. 2022 Oct;59(10):5955-5969. [Content Brief]
- [2]. Font J, et al. Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator. Elife. 2018 Jan 8;7:e34752. [Content Brief]
Keywords
