769973-37-7
Chemical Structure
Huwentoxin I
Synonym(s): HWTX-I
- CAS No.: 769973-37-7
- Formula:C161H246N48O44S6
- Molecular Weight:3750.36
SMILES: O=C([C@@H](N)C)N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CCCCN)=O)CC4=CNC5=CC=CC=C45)=O)CCCCN)=O)=O)CCC(O)=O)=O)CC(N)=O)=O)CCCCN)=O)=O)CCC1)=O)[C@@H](C)O)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC7=CNC8=CC=CC=C78)=O)CCCCN)=O)CC9=CNC=N9)=O)CCCCN)=O)CC(O)=O)=O)CO)=O)=O)C)=O)CC(O)=O)=O)CC%10=CC=CC=C%10)=O)C(C)C)=O)=O)CCCCN)=O)CSSC[C@H](NC2=O)C(N%11[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6C(C)C)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CCC%11)=O
Biological Activity: Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC50 values of 66.1 and 4.80 nM, respectively[1].
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Huwentoxin I | Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC50 values of 66.1 and 4.80 nM, respectively. | |||||||||||||||||||||
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Keywords
