82189-04-6
Chemical Structure
Ansatrienin B
Synonym(s): Mycotrienin II
- CAS No.: 82189-04-6
- Formula:C36H50N2O8
- Molecular Weight:638.79
IUPAC Name: (5R,6E,8E,10E,13S,14R,15R,16Z)-12,15,15-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-aza-1(1,3)-benzenacyclononadecaphane-6,8,10,16-tetraen-13-yl (cyclohexanecarbonyl)-D-alaninate
InChIKey: VVJDHJZQBGWPEQ-UOZMSBJPSA-N
SMILES: O=C(C1CCCCC1)N[C@@H](C(O[C@@H](C/C=C/C=C/C=C/[C@@H](C2)OC)[C@@H]([C@H](/C(C)=C\CCC3=CC(O)=CC(NC2=O)=C3O)O)C)=O)C
Biological Activity: Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin[1][2].
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Ansatrienin B | Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin. | |||||||||||||||||||||
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- [1]. M Sugita, et al. Studies on Mycotrienin Antibiotics, a Novel Class of Ansamycins. I. Taxonomy, Fermentation, Isolation and Properties of Mycotrienins I and II. J Antibiot (Tokyo). 1982 Nov;35(11):1460-6. [Content Brief]
- [2]. D Feuerbach, et al. Mycotrienins. A New Class of Potent Inhibitors of Osteoclastic Bone Resorption. J Biol Chem. 1995 Oct 27;270(43):25949-55. [Content Brief]
Keywords
