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  3. Ansatrienin B

Ansatrienin B (Synonyms: Mycotrienin II)

Cat. No.: HY-122306
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Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin.

For research use only. We do not sell to patients.

Ansatrienin B Chemical Structure

Ansatrienin B Chemical Structure

CAS No. : 82189-04-6

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Description

Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin[1][2].

In Vitro

Ansatrienin B exhibits antimicrobial activities of Penicillium chrysogenuin 1AM 7106, Mucor pusillus IAM 6122, Rhizopus delemar IAM 6015, Saccharornyces cerevisiae IFO 0304, Candida utilus IFO 0396 and Candida krusei IFO 0590 with MIC values of 12.5 μg/ml, 12.5 μg/ml, 12.5 μg/ml, 8.0 μg/ml, 4.0 μg/ml, 4.0 μg/ml, and 4.0 μg/ml, respectively[1].
Ansatrienin B inhibits the release of 45calcium into the culture medium by fetal rat long bones with an apparent halfmaximal inhibition (IC50) value of 21 nM[2].
Ansatrienin B inhibits the translationof the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50=58 nM) in A549 cells). At the same time, it also inhibits TNF-α-induced expression of ICAM-1 with an IC50 of 300 nM[3].

In Vivo

Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice[2].

Molecular Weight

638.79

Formula

C₃₆H₅₀N₂O₈

CAS No.

82189-04-6

SMILES

O=C(C1CCCCC1)N[[email protected]@H](C(O[[email protected]@H](C/C=C/C=C/C=C/[[email protected]@H](C2)OC)[[email protected]@H]([[email protected]](/C(C)=C\CCC3=CC(O)=CC(NC2=O)=C3O)O)C)=O)C

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ansatrienin BMycotrienin IIAntibioticBacterialPenicillium chrysogenuinRhizopus delemarantibioticStreptomycesADC ToxinInhibitorinhibitorinhibit

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