82451-20-5
Chemical Structure
Negundoside
- CAS No.: 82451-20-5
- Formula:C23H28O12
- Molecular Weight:496.46
InChIKey: RFCSGMIUBXUYSE-KLZCBZFCSA-N
SMILES: OC(C1=CO[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)OC(C3=CC=C(C=C3)O)=O)[C@@]4([H])[C@]1([H])CC[C@@]4(O)C)=O
Biological Activity: Negundoside is an iridoid glycoside compound. Negundoside exhibits hepatoprotective effects, reduces ROS, lipid peroxidation and intracellular calcium ion levels, and prevents the decrease of mitochondrial membrane potential (MMP) and apoptosis (apoptosis). Negundoside has neuroprotective effects, improves behavioral deficits, alleviates oxidative damage, and ameliorates cerebral infarction. Negundoside also possesses antibacterial and antiparasitic activities[1][2][3][4].
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Negundoside | Negundoside is an iridoid glycoside compound. Negundoside exhibits hepatoprotective effects, reduces ROS, lipid peroxidation and intracellular calcium ion levels, and prevents the decrease of mitochondrial membrane potential (MMP) and apoptosis (apoptosis). Negundoside has neuroprotective effects, improves behavioral deficits, alleviates oxidative damage, and ameliorates cerebral infarction. Negundoside also possesses antibacterial and antiparasitic activities. | |||||||||||||||||||||
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- [1]. Kabilan SJ, et al. Pharmacoinformatics-based screening of active compounds from Vitex negundo against lymphatic filariasis by targeting asparaginyl-tRNA synthetase. J Mol Model. 2023;29(4):87. Published 2023 Mar 6. [Content Brief]
- [2]. Tasduq SA, et al. Negundoside, an irridiod glycoside from leaves of Vitex negundo, protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride. World J Gastroenterol. 2008;14(23):3693-3709. [Content Brief]
- [3]. Islam Z, et al. Vitex Genus as a Source of Antimicrobial Agents. Plants (Basel). 2024 Jan 29;13(3):401. [Content Brief]
- [4]. Mehta K, et al. Vitex negundo protects against cerebral ischemia-reperfusion injury in mouse via attenuating behavioral deficits and oxidative damage. Psychopharmacology (Berl). 2022;239(2):573-587. [Content Brief]
Keywords
