832082-44-7
Chemical Structure
THRX160209
- CAS No.: 832082-44-7
- Formula:C42H60N4O3
- Molecular Weight:668.95
InChIKey: AXSAVLPYCZEECW-PSXMRANNSA-N
SMILES: COC1=C(C(OC)=CC=C1)CN2CCC(N(CCCCCCCN3C[C@H](C(C4=CC=CC=C4)(C(N)=O)C5=CC=CC=C5)CC3)CCC)CC2
Biological Activity: THRX160209 is a dual-site antagonist of the M2 muscarinic acetylcholine receptor with M2 receptor subtype selectivity. THRX160209 binds simultaneously to the orthosteric site and a spatially distinct allosteric site, competitively inhibiting receptor activation at the acetylcholine binding pocket. THRX160209 exhibits affinity for all five muscarinic receptor subtypes. THRX160209 can be used in research related to neurological disorders[1][2].
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THRX160209 | THRX160209 is a dual-site antagonist of the M2 muscarinic acetylcholine receptor with M2 receptor subtype selectivity. THRX160209 binds simultaneously to the orthosteric site and a spatially distinct allosteric site, competitively inhibiting receptor activation at the acetylcholine binding pocket. THRX160209 exhibits affinity for all five muscarinic receptor subtypes. THRX160209 can be used in research related to neurological disorders. | |||||||||||||||||||||
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References
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[1]. Steinfeld T, et al. A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor. Molecular Pharmacology, 2007, 72: 291-302.
- [2]. Kruse AC, et al. Muscarinic acetylcholine receptors: novel opportunities for drug development. Nature reviews. Drug discovery. 2014 Jul;13(7):549-60.
