83539-21-3
Chemical Structure
CK0683A
- CAS No.: 83539-21-3
- Formula:C32H57N9O5S
- Molecular Weight:679.92
InChIKey: LJDCZTFYPZNDAD-UHFFFAOYSA-N
SMILES: O=C(NC12CC3CC(C2)CC(C1)C3)NC(NCCCN(CCCNC(NC(NC45CC6CC(C5)CC(C4)C6)=O)=N)C)=N.O=S(O)(C)=O
Biological Activity: CK0683A is a novel biaminourea antibiotic with antiplaque effects and demonstrated efficacy in experimental mouse dental disease models. A 12-week study in beagles compared its efficacy in terms of plaque and gingivitis reduction, staining potential, and safety. Dogs were selected as the study subjects because the onset and progression of canine periodontal disease is similar to that of humans. As a positive control for plaque and gingivitis reduction and staining, chlorhexidine acetate was selected because it is effective in both humans and dogs.
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CK0683A | CK0683A is a novel biaminourea antibiotic with antiplaque effects and demonstrated efficacy in experimental mouse dental disease models. A 12-week study in beagles compared its efficacy in terms of plaque and gingivitis reduction, staining potential, and safety. Dogs were selected as the study subjects because the onset and progression of canine periodontal disease is similar to that of humans. As a positive control for plaque and gingivitis reduction and staining, chlorhexidine acetate was selected because it is effective in both humans and dogs. | |||||||||||||||||||||
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Keywords
