837369-26-3
837369-26-3
Chemical Structure
Pafuramidine maleate
Synonym(s): DB289 maleate
- CAS No.: 837369-26-3
- Formula:C24H24N4O7
- Molecular Weight:480.47
IUPAC Name: 4,4'-(furan-2,5-diyl)bis(N-methoxybenzimidamide) maleate
InChIKey: SWMNGXODFOCPKQ-BTJKTKAUSA-N
SMILES: OC(/C=C\C(O)=O)=O.N=C(C1=CC=C(C2=CC=C(C3=CC=C(C(NOC)=N)C=C3)O2)C=C1)NOC
Biological Activity: Pafuramidine (maleate) (DB289 (maleate)) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine (maleate) (DB289 (maleate)) is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria[1][2][3].
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Pafuramidine maleate | Pafuramidine (maleate) (DB289 (maleate)) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine (maleate) (DB289 (maleate)) is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria. | |||||||||||||||||||||
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References
- [1]. Mdachi RE, et al. Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration. Antimicrob Agents Chemother. 2009 Mar;53(3):953-7. [Content Brief]
- [2]. Pohlig G, et al. Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial. PLoS Negl Trop Dis. 2016 Feb 16;10(2):e0004363. [Content Brief]
- [3]. Chen D, et al. Pafuramidine for Pneumocystis jiroveci pneumonia in HIV-infected individuals. Expert Rev Anti Infect Ther. 2007 Dec;5(6):921-8. [Content Brief]
Keywords
