84014-70-0
Chemical Structure
Aristoloside
- CAS No.: 84014-70-0
- Formula:C23H21NO13
- Molecular Weight:519.41
IUPAC Name: 8-methoxy-6-nitro-10-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
InChIKey: GMKHAVDYTAXBIY-BSTKLLGTSA-N
SMILES: COC1=C2C(C3=C4C(OCO4)=CC(C(O)=O)=C3C([N+]([O-])=O)=C2)=CC(O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)=C1
Biological Activity: Aristoloside is an orally active aristolactam-type glycoside natural product found in Aristolochia manshuriensis, and is also a derivative of Aristolochic acid. Aristoloside exhibits anti-breast cancer activity and can be used in breast cancer-related research[1][2][3].
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Aristoloside | Aristoloside is an orally active aristolactam-type glycoside natural product found in Aristolochia manshuriensis, and is also a derivative of Aristolochic acid. Aristoloside exhibits anti-breast cancer activity and can be used in breast cancer-related research. | |||||||||||||||||||||
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References
- [1]. Hegde VR, et al. New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme. Bioorganic & medicinal chemistry letters. 2010 Feb 15;20(4):1344-6.
- [2]. Nagasawa H. Effects of aristoloside, a component of guan-mu-tong (Caulis aristolochiae manshuriensis), on normal and preneoplastic mammary gland growth in mice. Anticancer Res. 1997 Jan-Feb;17(1A):237-40.
- [3]. Mathew JE, et al. Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica. Iranian journal of basic medical sciences. 2011 Sep;14(5):422-7.
