846056-87-9
Chemical Structure
NVC-422
- CAS No.: 846056-87-9
- Formula:C4H9Cl2NO3S
- Molecular Weight:222.09
IUPAC Name: 2-(dichloroamino)-2-methylpropane-1-sulfonic acid
InChIKey: QYNRGGHZWCUZLK-UHFFFAOYSA-N
SMILES: CC(C)(N(Cl)Cl)CS(=O)(O)=O
Biological Activity: NVC-422 is a N-chlorotaurine analog, virucidal agent, antibacterial agent. NVC-422 exhibits virucidal activity against Ad5 by the oxidative inactivation of key viral proteins (fiber and hexon), leading to the loss of viral integrity and infectivity. NVC-422 is shown to be highly effective in killing all microbial strains tested, including antibiotic-resistant S. aureus and E. faecium. NVC-422 can be used in the research of adenoviral conjunctivitis[1][2].
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NVC-422 | NVC-422 is a N-chlorotaurine analog, virucidal agent, antibacterial agent. NVC-422 exhibits virucidal activity against Ad5 by the oxidative inactivation of key viral proteins (fiber and hexon), leading to the loss of viral integrity and infectivity. NVC-422 is shown to be highly effective in killing all microbial strains tested, including antibiotic-resistant S. aureus and E. faecium. NVC-422 can be used in the research of adenoviral conjunctivitis. | |||||||||||||||||||||
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- [1]. Yoon J, et al. Virucidal mechanism of action of NVC-422, a novel antimicrobial drug for the treatment of adenoviral conjunctivitis. Antiviral Res. 2011 Dec;92(3):470-8. [Content Brief]
- [2]. Wang L, et al. Chemical characterization and biological properties of NVC-422, a novel, stable N-chlorotaurine analog. Antimicrob Agents Chemother. 2011 Jun;55(6):2688-92. [Content Brief]
Keywords
