86304-28-1
86304-28-1
Chemical Structure
(R)-Buciclovir
- CAS No.: 86304-28-1
- Formula:C9H13N5O3
- Molecular Weight:239.24
IUPAC Name: (R)-2-amino-9-(3,4-dihydroxybutyl)-3,9-dihydro-6H-purin-6-one
InChIKey: QOVUZUCXPAZXDZ-RXMQYKEDSA-N
SMILES: C(C[C@H](CO)O)N1C2=C(N=C1)C(=O)N=C(N)N2
Biological Activity: (R)-Buciclovir is an orally active acyclic guanosine analog anti-herpetic agent that, following selective phosphorylation by HSV thymidine kinase, generates a triphosphate metabolite that inhibits viral DNA polymerase and DNA synthesis, thereby exerting anti-HSV activity. (R)-Buciclovir can be used for research on herpes simplex virus infection and genital herpes[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
(R)-Buciclovir | (R)-Buciclovir is an orally active acyclic guanosine analog anti-herpetic agent that, following selective phosphorylation by HSV thymidine kinase, generates a triphosphate metabolite that inhibits viral DNA polymerase and DNA synthesis, thereby exerting anti-HSV activity. (R)-Buciclovir can be used for research on herpes simplex virus infection and genital herpes. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Lundgren B, et al. Efficacy of the acyclic guanosine analog buciclovir [(R)-9-(3,4-dihydroxybutyl)guanine] in experimental genital herpes. Antimicrobial agents and chemotherapy. 1986 Feb;29(2):294-7.
- [2]. Larsson A, et al. Mode of action, toxicity, pharmacokinetics, and efficacy of some new antiherpesvirus guanosine analogs related to buciclovir. Antimicrobial agents and chemotherapy. 1986 Oct;30(4):598-605.
- [3]. Qin T, et al. Synthesis of Chiral Acyclic Nucleosides by Sharpless Asymmetric Dihydroxylation: Access to Cidofovir and Buciclovir. The Journal of organic chemistry. 2018 Dec 21;83(24):15512-15523.
- [4]. Chiou HC, et al. Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine. Antimicrobial agents and chemotherapy. 1986 Sep;30(3):502-4.
