863888-33-9
Chemical Structure
Flurpiridaz
- CAS No.: 863888-33-9
- Formula:C18H22ClFN2O3
- Molecular Weight:368.83
IUPAC Name: 2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)pyridazin-3(2H)-one
InChIKey: RMXZKEPDYBTFOS-UHFFFAOYSA-N
SMILES: O=C1C(Cl)=C(OCC2=CC=C(C=C2)COCCF)C=NN1C(C)(C)C
Biological Activity: Flurpiridaz is a positron emission tomography (PET) myocardial perfusion imaging tracer. Flurpiridaz can bind to mitochondrial complex I with high affinity. Flurpiridaz demonstrates high heart uptake in multiple species with clear delineation of perfusion deficits. Flurpiridaz shows rapid uptake in the myocardium. Flurpiridaz can be studied in research on coronary artery disease[1][2].
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Flurpiridaz | 98.73% | Flurpiridaz is a positron emission tomography (PET) myocardial perfusion imaging tracer. Flurpiridaz can bind to mitochondrial complex I with high affinity. Flurpiridaz demonstrates high heart uptake in multiple species with clear delineation of perfusion deficits. Flurpiridaz shows rapid uptake in the myocardium. Flurpiridaz can be studied in research on coronary artery disease. | ||||||||||||||||||||
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- [1]. Maddahi J, et al., Phase-III Clinical Trial of Fluorine-18 Flurpiridaz Positron Emission Tomography for Evaluation of Coronary Artery Disease. J Am Coll Cardiol. 2020 Jul 28;76(4):391-401. [Content Brief]
- [2]. Yu M, et al., The next generation of cardiac positron emission tomography imaging agents: discovery of flurpiridaz F-18 for detection of coronary disease. Semin Nucl Med. 2011 Jul;41(4):305-13. [Content Brief]
Keywords
