Flurpiridaz
Based on 1 Customer Validation
Flurpiridaz is a positron emission tomography (PET) myocardial perfusion imaging tracer. Flurpiridaz inhibits mitochondrial complex I, binds to complex I with high affinity (IC50 16.6 nM), and blocks electron transport. Flurpiridaz can be used for research on ischemia-reperfusion.
For research use only. We do not sell to patients.
- Purity : 98.73%
- CAS No.: 863888-33-9
- Formula: C18H22ClFN2O3
- Molecular Weight:368.83
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
complex I 16.6 nM (IC50) |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 863888-33-9
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Appearance Solid
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Molecular Weight 368.83
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Formula C18H22ClFN2O3
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Color White to off-white
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SMILES
O=C1C(Cl)=C(OCC2=CC=C(C=C2)COCCF)C=NN1C(C)(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (67.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (271 KB)
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SDS (624 KB)
- English - EN (624 KB)
- Français - FR (624 KB)
- Deutsch - DE (624 KB)
- Norwegian - NO (624 KB)
- Español - ES (624 KB)
- Swedish - SV (624 KB)
- Italian - IT (624 KB)
- Korean - KR (624 KB)
- Portuguese - PT (624 KB)
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Handling Instructions (2659 KB)
References
[1]. Yu M, et al. The next generation of cardiac positron emission tomography imaging agents: discovery of flurpiridaz F-18 for detection of coronary disease. Seminars in nuclear medicine. 2011 Jul;41(4):305-13. [Content Brief]
[2]. Papadimitriou L, et al. Utility of positron emission tomography for drug development for heart failure. American heart journal. 2016 May;175:142-52. [Content Brief]
[3]. Packard RRS, et al. Development, diagnostic performance, and interobserver agreement of a F-flurpiridaz PET automated perfusion quantitation system. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 2022 Apr;29(2):698-708. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7113 mL | 13.5564 mL | 27.1128 mL | 67.7819 mL |
| 5 mM | 0.5423 mL | 2.7113 mL | 5.4226 mL | 13.5564 mL | |
| 10 mM | 0.2711 mL | 1.3556 mL | 2.7113 mL | 6.7782 mL | |
| 15 mM | 0.1808 mL | 0.9038 mL | 1.8075 mL | 4.5188 mL | |
| 20 mM | 0.1356 mL | 0.6778 mL | 1.3556 mL | 3.3891 mL | |
| 25 mM | 0.1085 mL | 0.5423 mL | 1.0845 mL | 2.7113 mL | |
| 30 mM | 0.0904 mL | 0.4519 mL | 0.9038 mL | 2.2594 mL | |
| 40 mM | 0.0678 mL | 0.3389 mL | 0.6778 mL | 1.6945 mL | |
| 50 mM | 0.0542 mL | 0.2711 mL | 0.5423 mL | 1.3556 mL | |
| 60 mM | 0.0452 mL | 0.2259 mL | 0.4519 mL | 1.1297 mL |
Flurpiridaz Related Classifications
HY-180344 Related Classifications
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Keywords
- Flurpiridaz
- 863888-33-9
- Biochemical Assay Reagents
- Mitochondrial Metabolism
- PET myocardial perfusion radiotracer
- cardiac myocytes
- coronary artery disease
- electron transport chain
- first-pass extraction
- mitochondrial complex I inhibitor
- myocardial blood flow
- myocardial infarction
- myocardial perfusion defects
- myocardial uptake
- Inhibitor
- inhibitor
- inhibit