Flurpiridaz
Based on 1 Customer Validation
Flurpiridaz is a positron emission tomography (PET) myocardial perfusion imaging tracer. Flurpiridaz can bind to mitochondrial complex I with high affinity. Flurpiridaz demonstrates high heart uptake in multiple species with clear delineation of perfusion deficits. Flurpiridaz shows rapid uptake in the myocardium. Flurpiridaz can be studied in research on coronary artery disease.
For research use only. We do not sell to patients.
- Purity: 98.73%
- CAS No.: 863888-33-9
- Formula: C18H22ClFN2O3
- Molecular Weight:368.83
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 863888-33-9
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Appearance Solid
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Molecular Weight 368.83
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Formula C18H22ClFN2O3
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Color White to off-white
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SMILES
O=C1C(Cl)=C(OCC2=CC=C(C=C2)COCCF)C=NN1C(C)(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (67.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (624 KB)
- English - EN (624 KB)
- Français - FR (624 KB)
- Deutsch - DE (624 KB)
- Norwegian - NO (624 KB)
- Español - ES (624 KB)
- Swedish - SV (624 KB)
- Italian - IT (624 KB)
- Korean - KR (624 KB)
- Portuguese - PT (624 KB)
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Handling Instructions (2659 KB)
References
[1]. Maddahi J, et al., Phase-III Clinical Trial of Fluorine-18 Flurpiridaz Positron Emission Tomography for Evaluation of Coronary Artery Disease. J Am Coll Cardiol. 2020 Jul 28;76(4):391-401. [Content Brief]
[2]. Yu M, et al., The next generation of cardiac positron emission tomography imaging agents: discovery of flurpiridaz F-18 for detection of coronary disease. Semin Nucl Med. 2011 Jul;41(4):305-13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7113 mL | 13.5564 mL | 27.1128 mL | 67.7819 mL |
| 5 mM | 0.5423 mL | 2.7113 mL | 5.4226 mL | 13.5564 mL | |
| 10 mM | 0.2711 mL | 1.3556 mL | 2.7113 mL | 6.7782 mL | |
| 15 mM | 0.1808 mL | 0.9038 mL | 1.8075 mL | 4.5188 mL | |
| 20 mM | 0.1356 mL | 0.6778 mL | 1.3556 mL | 3.3891 mL | |
| 25 mM | 0.1085 mL | 0.5423 mL | 1.0845 mL | 2.7113 mL | |
| 30 mM | 0.0904 mL | 0.4519 mL | 0.9038 mL | 2.2594 mL | |
| 40 mM | 0.0678 mL | 0.3389 mL | 0.6778 mL | 1.6945 mL | |
| 50 mM | 0.0542 mL | 0.2711 mL | 0.5423 mL | 1.3556 mL | |
| 60 mM | 0.0452 mL | 0.2259 mL | 0.4519 mL | 1.1297 mL |
Flurpiridaz Related Classifications
HY-180344 Related Classifications
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