865305-30-2
865305-30-2
Chemical Structure
AF-353
Synonym(s): Ro-4
- CAS No.: 865305-30-2
- Formula:C14H17IN4O2
- Molecular Weight:400.21
IUPAC Name: 5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine
InChIKey: AATPYXMXFBBKFO-UHFFFAOYSA-N
SMILES: CC(C)C1=C(OC2=CN=C(N)N=C2N)C=C(I)C(OC)=C1
Biological Activity: AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2].
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AF-353 | 99.43% | AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3. | ||||||||||||||||||||
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AF-353 (Standard) | ≥98% | AF-353 (Standard) is the analytical standard of AF-353. This product is intended for research and analytical applications. AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3. | ||||||||||||||||||||
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References
- [1]. Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-1398. [Content Brief]
- [2]. Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110(8 Pt B):E409-414. [Content Brief]
Keywords
