910661-33-5
Chemical Structure
EC-17 disodium salt
- CAS No.: 910661-33-5
- Formula:C42H34N10Na2O10S
- Molecular Weight:916.82
IUPAC Name: sodium N2-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N5-(2-(3-(3'-hydroxy-6'-oxido-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)thioureido)ethyl)-L-glutaminate
InChIKey: DDZCXWNVKVTDID-ARIINYJRSA-L
SMILES: S=C(NCCNC(CC[C@@H](C(O[Na])=O)NC(C1=CC=C(NCC2=CN=C3N=C(N)NC(C3=N2)=O)C=C1)=O)=O)NC4=CC5=C(C6(C7=C(OC8=C6C=CC(O)=C8)C=C(O[Na])C=C7)OC5=O)C=C4
Biological Activity: EC-17 disodium salt is a folate receptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The EC-17 maximum excitation and emission wavelengths are 490 nm and 520 nm, respectively[1][2].
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EC-17 disodium salt | EC-17 disodium salt is a folate receptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The EC-17 maximum excitation and emission wavelengths are 490 nm and 520 nm, respectively. | |||||||||||||||||||||
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References
- [1]. Tummers QR, et al. Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17. Oncotarget. 2016 May 31;7(22):32144-55. [Content Brief]
- [2]. Patil RA, et al. Fluorescence Labeling of Circulating Tumor Cells with a Folate Receptor-Targeted Molecular Probe for Diffuse In Vivo Flow Cytometry. Mol Imaging Biol. 2020 Oct;22(5):1280-1289. [Content Brief]
