932705-04-9
932705-04-9
Chemical Structure
MK-1925
- CAS No.: 932705-04-9
- Formula:C19H21F3N4
- Molecular Weight:362.40
IUPAC Name: 3-(5-(3,5-difluorophenyl)-3-((((1S,3R)-3-fluorocyclopentyl)amino)methyl)-4-methyl-1H-pyrazol-1-yl)propanenitrile
InChIKey: LJTOZIFFXNLWEQ-PBHICJAKSA-N
SMILES: C(CC#N)N1C(=C(C)C(CN[C@@H]2C[C@H](F)CC2)=N1)C3=CC(F)=CC(F)=C3
Biological Activity: MK-1925 is an orally active, CNS-penetrant ORL1 receptor antagonist with an IC50 of 8.2 nM. MK-1925 selectively inhibits the ORL1 receptor and shows no significant activity against other opioid receptors or the hERG potassium channel[1].
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MK-1925 | MK-1925 is an orally active, CNS-penetrant ORL1 receptor antagonist with an IC50 of 8.2 nM. MK-1925 selectively inhibits the ORL1 receptor and shows no significant activity against other opioid receptors or the hERG potassium channel. | |||||||||||||||||||||
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References
Keywords
