937735-00-7
Chemical Structure
QM31
Synonym(s): SVT016426
- CAS No.: 937735-00-7
- Formula:C39H38Cl4N4O4
- Molecular Weight:768.56
IUPAC Name: N-(2-amino-2-oxoethyl)-N,1-bis(2,4-dichlorophenethyl)-4-(3,3-diphenylpropyl)-3,7-dioxo-1,4-diazepane-5-carboxamide
InChIKey: YSUHYGYGQFSKDT-UHFFFAOYSA-N
SMILES: O=C(C(C1)N(CCC(C2=CC=CC=C2)C3=CC=CC=C3)C(CN(CCC4=CC=C(Cl)C=C4Cl)C1=O)=O)N(CC(N)=O)CCC5=CC=C(Cl)C=C5Cl
Biological Activity: QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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QM31 | 95.00% | QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. | ||||||||||||||||||||
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- [1]. Mondragón L, et al. A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. Apoptosis. 2009 Feb;14(2):182-90. [Content Brief]
- [2]. Orzáez M, et al. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS One. 2014 Oct 20;9(10):e110979. [Content Brief]
Keywords
