1. Apoptosis
  2. Caspase
  3. QM31

QM31 (Synonyms: SVT016426)

Cat. No.: HY-125018
Handling Instructions

QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint.

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QM31 Chemical Structure

QM31 Chemical Structure

CAS No. : 937735-00-7

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Description

QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint[1][2].

In Vitro

SVT016426 (0.5-2 μM) inhibits Apaf1-induced activation of caspase activity with an IC50 of 5 μM in HeLa S100 cells[3].

Molecular Weight

768.56

Formula

C₃₉H₃₈Cl₄N₄O₄

CAS No.

937735-00-7

SMILES

O=C(C(C1)N(CCC(C2=CC=CC=C2)C3=CC=CC=C3)C(CN(CCC4=CC=C(Cl)C=C4Cl)C1=O)=O)N(CC(N)=O)CCC5=CC=C(Cl)C=C5Cl

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

QM31SVT016426QM 31QM-31SVT 016426SVT-016426CaspaseformationcytoprotectiveapoptosomecaspasemitochondrioprotectiveDNAdamagecheckpointInhibitorinhibitorinhibit

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