1. Apoptosis
  2. Caspase
  3. QM31

QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint.

For research use only. We do not sell to patients.

QM31 Chemical Structure

QM31 Chemical Structure

CAS No. : 937735-00-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 638 In-stock
Solution
10 mM * 1 mL in DMSO USD 638 In-stock
Solid
5 mg USD 580 In-stock
10 mg USD 980 In-stock
25 mg USD 1900 In-stock
50 mg USD 3200 In-stock
100 mg USD 5000 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint[1][2].

In Vitro

SVT016426 (0.5-2 μM) inhibits Apaf1-induced activation of caspase activity with an IC50 of 5 μM in HeLa S100 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

768.56

Formula

C39H38Cl4N4O4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C1)N(CCC(C2=CC=CC=C2)C3=CC=CC=C3)C(CN(CCC4=CC=C(Cl)C=C4Cl)C1=O)=O)N(CC(N)=O)CCC5=CC=C(Cl)C=C5Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (162.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3011 mL 6.5057 mL 13.0113 mL
5 mM 0.2602 mL 1.3011 mL 2.6023 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3011 mL 6.5057 mL 13.0113 mL 32.5284 mL
5 mM 0.2602 mL 1.3011 mL 2.6023 mL 6.5057 mL
10 mM 0.1301 mL 0.6506 mL 1.3011 mL 3.2528 mL
15 mM 0.0867 mL 0.4337 mL 0.8674 mL 2.1686 mL
20 mM 0.0651 mL 0.3253 mL 0.6506 mL 1.6264 mL
25 mM 0.0520 mL 0.2602 mL 0.5205 mL 1.3011 mL
30 mM 0.0434 mL 0.2169 mL 0.4337 mL 1.0843 mL
40 mM 0.0325 mL 0.1626 mL 0.3253 mL 0.8132 mL
50 mM 0.0260 mL 0.1301 mL 0.2602 mL 0.6506 mL
60 mM 0.0217 mL 0.1084 mL 0.2169 mL 0.5421 mL
80 mM 0.0163 mL 0.0813 mL 0.1626 mL 0.4066 mL
100 mM 0.0130 mL 0.0651 mL 0.1301 mL 0.3253 mL
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QM31 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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