944406-54-6
Chemical Structure
GSK945237
- CAS No.: 944406-54-6
- Formula:C24H26FN5O3
- Molecular Weight:451.49
IUPAC Name: (R)-1-((4-(((6,7-dihydro-[1,4]dioxino[2,3-c]pyridazin-3-yl)methyl)amino)piperidin-1-yl)methyl)-9-fluoro-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
InChIKey: SRICOHRDRMZREQ-MRXNPFEDSA-N
SMILES: O=C1N2C3=C([C@H](CN4CCC(NCC5=NN=C(OCCO6)C6=C5)CC4)C2)C(F)=CC=C3C=C1
Biological Activity: GSK945237 is a potent and orally active bacterial type IIA topoisomerases inhibitor. GSK945237 shows broad-spectrum activity against Gram-positive and Gram-negative bacteria (IC50 of 0.034 μg/mL against H. influenzae DNA gyrase). GSK945237 demonstrates good in vivo efficacy in a rat respiratory tract infection model. GSK945237 can be used for anti-infection research[1].
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GSK945237 | GSK945237 is a potent and orally active bacterial type IIA topoisomerases inhibitor. GSK945237 shows broad-spectrum activity against Gram-positive and Gram-negative bacteria (IC50 of 0.034 μg/mL against H. influenzae DNA gyrase). GSK945237 demonstrates good in vivo efficacy in a rat respiratory tract infection model. GSK945237 can be used for anti-infection research. | |||||||||||||||||||||
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Keywords
