95896-78-9
Chemical Structure
4,8-DiMeIQx
- CAS No.: 95896-78-9
- Formula:C12H13N5
- Molecular Weight:227.27
IUPAC Name: 2-(methoxymethyl)pyrimidine-5-carbaldehyde
InChIKey: LAZSIJHHPMHKQI-UHFFFAOYSA-N
SMILES: NC(N1C)=NC2=C1C(C)=CC3=C2N=C(C)C=N3
Biological Activity: 4,8-DiMeIQx is an orally active mutagen, selective dopaminergic neurotoxicant, and DNA damaging agent. 4,8-DiMeIQx can be isolated from cooked beef, sausage, pork, and chicken. 4,8-DiMeIQx induces reverse mutations in *Salmonella typhimurium* TA98 in the presence or absence of S9 mix, and forms DNA adducts in vivo in rat liver. 4,8-DiMeIQx exhibits selective neurotoxicity toward dopaminergic neurons. 4,8-DiMeIQx shows no activity against non-dopaminergic neurons. 4,8-DiMeIQx can be used in studies related to Parkinson's disease and colorectal cancer[1][2][3][4].
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4,8-DiMeIQx | 4,8-DiMeIQx is an orally active mutagen, selective dopaminergic neurotoxicant, and DNA damaging agent. 4,8-DiMeIQx can be isolated from cooked beef, sausage, pork, and chicken. 4,8-DiMeIQx induces reverse mutations in *Salmonella typhimurium* TA98 in the presence or absence of S9 mix, and forms DNA adducts in vivo in rat liver. 4,8-DiMeIQx exhibits selective neurotoxicity toward dopaminergic neurons. 4,8-DiMeIQx shows no activity against non-dopaminergic neurons. 4,8-DiMeIQx can be used in studies related to Parkinson's disease and colorectal cancer. | |||||||||||||||||||||
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2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline-d3 | 2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline-d3 is the deuterium labeled 2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline. | |||||||||||||||||||||
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- [1]. Takahashi M, et al. Identification and quantification of 2-amino-3,4,8-trimethylimidazo- [4,5-f]quinoxaline (4,8-DiMeIQx) in beef extract. Carcinogenesis. 1985 Oct;6(10):1537-9. [Content Brief]
- [2]. Cruz-Hernandez A, et al. Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons. Neurotoxicology. 2018 Mar;65:68-84. [Content Brief]
- [3]. Frandsen H, et al. Formation of DNA adducts by the food mutagen 2-amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxaline (4,8-DiMeIQx) in vitro and in vivo. Identification of a N2-(2'-deoxyguanosin-8-yl)-4,8-DiMeIQx adduct. Carcinogenesis. 1994 Nov;15(11):2553-8. [Content Brief]
- [4]. Knize MG, et al. The metabolism of 4,8-DiMeIQx in conventional and germ-free rats. Carcinogenesis. 1989 Aug;10(8):1479-84. [Content Brief]
