country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-146071

Copy Link Print Information

Antitrypanosomal agent 5

Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC₅₀s of 1 nM and 483.3 µM against T. brucei cell growth and HEK293 cells growth , respectively.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₀H₃₀N₆O₄S
Molecular Weight:570.66

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Antitrypanosomal agent 5 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC₅₀s of 1 nM and 483.3 µM against T. brucei cell growth and HEK293 cells growth , respectively^[1].

Alle Parasite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	483.3 μM Compound: 25	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 35396128]
RAW264.7	IC₅₀	>500 μM Compound: 25	Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 35396128]

In Vitro

After dosing T. brucei cells with Antitrypanosomal agent 5 (Compound 25; 200-1000 nM) for 12 hours, Western blot analyses shows Antitrypanosomal agent 5 inhibits tubulin polymerization in T. brucei cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:

T. brucei cells^[1]
Concentration:

200nM; 500 nM; 1000 nM
Incubation Time:

12 hours
Result:

Polymerized tubulin in T. brucei cells was significantly decreased with the treatment of Antitrypanosomal agent 5 at 500 nM and 1000 nM.

Chemical Information

Molecular Weight 570.66
Formel C₃₀H₃₀N₆O₄S
SMILES

CN(S(=O)(CC1=CC=CC=C1)=O)C2=CC=C(C=C2OCC3=CC=C(C=C3)C(N)=N)NC(C4=CC=CC(C(N)=N)=C4)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Viharika Bobba, et al. Synthesis and biological evaluation of imidamide analogs as selective anti-trypanosomal agents. Bioorg Med Chem. 2022 May 1;61:116740. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen