2767446-03-5
Chemical Structure
Mu opioid receptor antagonist 1
- CAS. Nr.: 2767446-03-5
- Formula:C24H28N4O4
- Molecular Weight:436.50
IUPAC Name: N-((4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl)-1H-imidazole-5-carboxamide
InChIKey: SPUWCPMVVGFCLA-GLLLEQLPSA-N
SMILES: O[C@]12[C@H]3CC4=C5[C@@]1(CCN3CC6CC6)[C@H]([C@@H](CC2)NC(C7=CN=CN7)=O)OC5=C(O)C=C4
Biological Activity: Mu opioid receptor antagonist 1 (compound 19) is a selective and orally active μ opioid receptor (MOR) ligand with an Ki value of 0.58 nM and an EC50 of 1.15 nM. Orally administrating with Mu opioid receptor antagonist 1 increases intestinal motility during morphine-induced constipation. Mu opioid receptor antagonist 1 can be used for researching opioid-induced constipation (OIC)[1].
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Mu opioid receptor antagonist 1 | Mu opioid receptor antagonist 1 (compound 19) is a selective and orally active μ opioid receptor (MOR) ligand with an Ki value of 0.58 nM and an EC50 of 1.15 nM. Orally administrating with Mu opioid receptor antagonist 1 increases intestinal motility during morphine-induced constipation. Mu opioid receptor antagonist 1 can be used for researching opioid-induced constipation (OIC). | |||||||||||||||||||||
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