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Art. -Nr.: HY-N21794

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Dendrobine-N-oxide

Dendrobine-N-oxide is a dendrobine-type sesquiterpene alkaloid. It is isolated from Dendrobium nobile. Dendrobine-N-oxide inhibits neuroinflammation, reduces β-Amyloid accumulation, enhances the expression of neurotrophic factors, suppresses the hyperphosphorylation of Tau protein, and exerts anti-neuronal Apoptosis effects. Dendrobine-N-oxide shows no anticancer activity against colon cancer and pancreatic adenocarcinoma. It is used in research on neurodegenerative diseases.

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CAS. Nr.: 40072-57-9
Formel: C₁₆H₂₅NO₃
Molecular Weight:279.37

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dendrobine-N-oxide Chemical Structure

CAS. Nr.: 40072-57-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC50	>50 μM	Cytotoxicity against human HCT-116 colon tumour cells measured by MTT assay. Cytotoxicity against human HCT-116 colon tumour cells measured by MTT assay.	34930072
SW1990	IC50	>50 μM	Cytotoxicity against human SW1990 pancreatic tumour cells measured by MTT assay. Cytotoxicity against human SW1990 pancreatic tumour cells measured by MTT assay.	34930072

In Vitro

Dendrobine-N-oxide (up to 50 μM) exhibits no cytotoxic activity against human HCT-116 and SW1990 cell lines, with IC₅₀ values exceeding 50 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 40072-57-9
Molecular Weight 279.37
Formel C₁₆H₂₅NO₃
SMILES

C[C@@]12[C@@]3([H])[C@@]4([H])[C@H]([C@@](C(O4)=O)([H])[C@]1([H])CC[C@]2([H])C[N+]3([O-])C)C(C)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Yang C, et al. Research Progress on the Alkaloids of Dendrobium nobile: Substantiation, Key Components, Pharmacological Activity, and Biosynthetic Pathways. Curr Issues Mol Biol. 2026 May 29;48(6):570.

[2]. Liu Q, et al. Metabolic profiling, in-situ spatial distribution, and biosynthetic pathway of functional metabolites in Dendrobium nobile stem revealed by combining UPLC-QTOF-MS with MALDI-TOF-MSI. Front Plant Sci. 2023 Jan 12;13:1125872.

[3]. Zhang MS, et al. Dendrobine-type alkaloids from Dendrobium nobile. Nat Prod Res. 2022 Nov;36(21):5393-5399.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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