40072-57-9
Chemical Structure
Dendrobine-N-oxide
- CAS No.: 40072-57-9
- Formula:C16H25NO3
- Molecular Weight:279.37
IUPAC Name: (2aS,2a1R,4aS,5R,8R,8aS,9S)-9-isopropyl-2a1,4-dimethyl-7-oxodecahydro-1H-6-oxa-4-aza-5,8-methanocyclopenta[cd]azulene 4-oxide
InChIKey: RQDMKDHZQRCRSB-PALPPXOESA-N
SMILES: C[C@@]12[C@@]3([H])[C@@]4([H])[C@H]([C@@](C(O4)=O)([H])[C@]1([H])CC[C@]2([H])C[N+]3([O-])C)C(C)C
Biological Activity: Dendrobine-N-oxide is a dendrobine-type sesquiterpene alkaloid. It is isolated from Dendrobium nobile. Dendrobine-N-oxide inhibits neuroinflammation, reduces β-Amyloid accumulation, enhances the expression of neurotrophic factors, suppresses the hyperphosphorylation of Tau protein, and exerts anti-neuronal Apoptosis effects. Dendrobine-N-oxide shows no anticancer activity against colon cancer and pancreatic adenocarcinoma. It is used in research on neurodegenerative diseases[1][2][3].
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Dendrobine-N-oxide | Dendrobine-N-oxide is a dendrobine-type sesquiterpene alkaloid. It is isolated from Dendrobium nobile. Dendrobine-N-oxide inhibits neuroinflammation, reduces β-Amyloid accumulation, enhances the expression of neurotrophic factors, suppresses the hyperphosphorylation of Tau protein, and exerts anti-neuronal Apoptosis effects. Dendrobine-N-oxide shows no anticancer activity against colon cancer and pancreatic adenocarcinoma. It is used in research on neurodegenerative diseases. | |||||||||||||||||||||
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References
- [1]. Yang C, et al. Research Progress on the Alkaloids of Dendrobium nobile: Substantiation, Key Components, Pharmacological Activity, and Biosynthetic Pathways. Curr Issues Mol Biol. 2026 May 29;48(6):570.
- [2]. Liu Q, et al. Metabolic profiling, in-situ spatial distribution, and biosynthetic pathway of functional metabolites in Dendrobium nobile stem revealed by combining UPLC-QTOF-MS with MALDI-TOF-MSI. Front Plant Sci. 2023 Jan 12;13:1125872.
- [3]. Zhang MS, et al. Dendrobine-type alkaloids from Dendrobium nobile. Nat Prod Res. 2022 Nov;36(21):5393-5399.
