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Cat. No.: HY-N21794

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Dendrobine-N-oxide

Dendrobine-N-oxide is a dendrobine-type sesquiterpene alkaloid. It is isolated from Dendrobium nobile. Dendrobine-N-oxide inhibits neuroinflammation, reduces β-Amyloid accumulation, enhances the expression of neurotrophic factors, suppresses the hyperphosphorylation of Tau protein, and exerts anti-neuronal Apoptosis effects. Dendrobine-N-oxide shows no anticancer activity against colon cancer and pancreatic adenocarcinoma. It is used in research on neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 40072-57-9
Formula: C₁₆H₂₅NO₃
Molecular Weight:279.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dendrobine-N-oxide Chemical Structure

CAS No.: 40072-57-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC50	>50 μM	Cytotoxicity against human HCT-116 colon tumour cells measured by MTT assay. Cytotoxicity against human HCT-116 colon tumour cells measured by MTT assay.	34930072
SW1990	IC50	>50 μM	Cytotoxicity against human SW1990 pancreatic tumour cells measured by MTT assay. Cytotoxicity against human SW1990 pancreatic tumour cells measured by MTT assay.	34930072

In Vitro

Dendrobine-N-oxide (up to 50 μM) exhibits no cytotoxic activity against human HCT-116 and SW1990 cell lines, with IC₅₀ values exceeding 50 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 40072-57-9
Molecular Weight 279.37
Formula C₁₆H₂₅NO₃
SMILES

C[C@@]12[C@@]3([H])[C@@]4([H])[C@H]([C@@](C(O4)=O)([H])[C@]1([H])CC[C@]2([H])C[N+]3([O-])C)C(C)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang C, et al. Research Progress on the Alkaloids of Dendrobium nobile: Substantiation, Key Components, Pharmacological Activity, and Biosynthetic Pathways. Curr Issues Mol Biol. 2026 May 29;48(6):570.

[2]. Liu Q, et al. Metabolic profiling, in-situ spatial distribution, and biosynthetic pathway of functional metabolites in Dendrobium nobile stem revealed by combining UPLC-QTOF-MS with MALDI-TOF-MSI. Front Plant Sci. 2023 Jan 12;13:1125872.

[3]. Zhang MS, et al. Dendrobine-type alkaloids from Dendrobium nobile. Nat Prod Res. 2022 Nov;36(21):5393-5399.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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