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CD300E - CD300e molecule Gene

Also Known as CLM2; CLM-2; IREM2; PIgR2; IREM-2; PIgR-2; CD300LE; CMRF35-A5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 342510

About CD300E

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:74,609,885-74,623,738 (from NCBI)

This gene has 2 transcripts (splice variants), 66 orthologues and 13 paralogues. Biased expression in appendix (RPKM 19.2), bone marrow (RPKM 15.3) and 4 other tissues.

Summary

This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]

CD300E Products (1)

mRNA	Protein	Name
NM_181449.3	NP_852114.2	CMRF35-like molecule 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20959446	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD300E Protein Structure

V-set

0
100
200
232 a.a.

Protein Preferred Names	Protein Names
CMRF35-like molecule 2	CD300 antigen-like family member E

CD300E Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CD300E	Q496F6	CTXN3	Homo sapiens	Q4LDR2	Validated Y2H	32296183
Intra	CD300E	Q496F6	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD300E Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P76223	CD300e Protein, Human (HEK293, Fc)	Q496F6 (L18-H173)	≥ 95%, as determined by reducing SDS-PAGE.

CD300E Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P811293	CD300e Antibody	WB	Human, Mouse, Rat
HY-P84985	CD300e Antibody (YA4677)	ELISA	Human

Related Diseases

Diseases	Alias
Tungiasis	Tunga Penetrans Infestation Chigger Flea S Penetrans Sarcopsylla Penetrans T Penetrans Tunga Penetrans Sand-Flea Infestation Jiggers Infestation Chigoe Infestation Jigger Disease
Amelogenesis Imperfecta, Type Ia	Amelogenesis Imperfecta Type 1a AI1A Amelogenesis Imperfecta, Hypoplastic Type Ia Amelogenesis Imperfecta Type Ia Amelogenesis Imperfecta Hypoplastic Type Ia Amelogenesis Imperfecta 1a
Myeloid Leukemia Associated With Down Syndrome
Lice Infestation	Pediculosis Louse Infestation Mixed Pediculosis Lice Infestations Infestation By Pediculus Mixed Pediculosis Infestation Pediculosis + Lice Pediculosis And Phthirus Infection Pediculosis And Phthirus Infections Pediculosis And Phthirus Infestation Infestation By Anoplura Pediculus Infestation Lice Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS02228	CD300E Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20535	Cd300e Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27044	Cd300e Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CD300E	VGNC	VGNC:38947
Mus musculus	CD300E	MGD	MGI:2387602
Macaca mulatta	CD300E	VGNC	VGNC:84878
Bos taurus	CD300E	VGNC	VGNC:57137
Rattus norvegicus	CD300E	RGD	RGD:1585137
Others	CD300E	NCBI