YWHAB - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta Gene

Also Known as HS1; GW128; YWHAA; KCIP-1; HEL-S-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7529

About YWHAB

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,885,705-44,908,532 (from NCBI)

This gene has 8 transcripts (splice variants), 269 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 158.2), lymph node (RPKM 85.8) and 24 other tissues.

Summary

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

YWHAB Products (2)

mRNA	Protein	Name
NM_003404.5	NP_003395.1	2014/3/3 protein beta/alpha
NM_139323.4	NP_647539.1	2014/3/3 protein beta/alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	17255105	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17085597	GOA
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables phosphoserine residue binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7644510	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11984006	GOA
enables protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	11555644	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cytoplasmic sequestering of protein	IDA IDA: Inferred from direct assay	10869435	GOA
involved in negative regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21224381	GOA
involved in positive regulation of catalytic activity	IDA IDA: Inferred from direct assay	17255105	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10869435	GOA
located in cytosol	IDA IDA: Inferred from direct assay	31906564	GOA
located in nucleus	IDA IDA: Inferred from direct assay	31906564	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12963375	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YWHAB Protein Structure

14-3-3

0
100
200
246 a.a.

Protein Preferred Names	Protein Names
14-3-3 protein beta/alpha	14-3-3 alpha

YWHAB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	YWHAB	P31946	CDK14	Homo sapiens	O94921	Anti Tag CoIP	36931259
Intra	YWHAB	P31946	CDK14	Homo sapiens	O94921	Anti Bait CoIP	16775625
Intra	YWHAB	P31946	YAP1	Homo sapiens	P46937	Anti Tag CoIP	35271311
Intra	YWHAB	P31946	YAP1	Homo sapiens	P46937	CoIP	17974916
Intra	YWHAB	P31946	YAP1	Homo sapiens	P46937	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	YAP1	Homo sapiens	P46937	BioID	36931259
Intra	YWHAB	P31946	PTPN3	Homo sapiens	P26045	Anti Tag CoIP	36931259
Intra	YWHAB	P31946	PTPN3	Homo sapiens	P26045	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	PTPN3	Homo sapiens	P26045	Anti Bait CoIP	17353931
Intra	YWHAB	P31946	CDC25B	Homo sapiens	P30305	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	CDC25B	Homo sapiens	P30305	CoIP	15173315
Intra	YWHAB	P31946	CDC25B	Homo sapiens	P30305	Y2H	7644510
Intra	YWHAB	P31946	DYRK1A	Homo sapiens	Q13627-2	Y2H	17229891
Intra	YWHAB	P31946	RMDN3	Homo sapiens	Q96TC7	IF	21972092
Intra	YWHAB	P31946	RMDN3	Homo sapiens	Q96TC7	Anti Bait CoIP	17353931
Intra	YWHAB	P31946	RMDN3	Homo sapiens	Q96TC7	PLA	21972092
Intra	YWHAB	P31946	RMDN3	Homo sapiens	Q96TC7	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	RND3	Homo sapiens	P61587	Pull Down	23622247
Intra	YWHAB	P31946	CRTC2	Homo sapiens	Q53ET0	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	CRTC2	Homo sapiens	Q53ET0	Pull Down	15454081
Intra	YWHAB	P31946	CRTC2	Homo sapiens	Q53ET0	Anti Tag CoIP	36931259
Intra	YWHAB	P31946	CRTC2	Homo sapiens	Q53ET0	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	CRTC2	Homo sapiens	Q53ET0	Anti Tag CoIP	35271311
Intra	YWHAB	P31946	SSH1	Homo sapiens	Q8WYL5	CoIP	15159416
Intra	YWHAB	P31946	AKAP13	Homo sapiens	Q12802	Anti Tag CoIP	35271311
Intra	YWHAB	P31946	AKAP13	Homo sapiens	Q12802	Anti Bait CoIP	17353931
Intra	YWHAB	P31946	AKAP13	Homo sapiens	Q12802	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	AKAP13	Homo sapiens	Q12802	BioID	36931259
Intra	YWHAB	P31946	ADAM22	Homo sapiens	Q9P0K1-3	Anti Tag CoIP	16868027
Intra	YWHAB	P31946	ADAM22	Homo sapiens	Q9P0K1-3	Y2H	16868027
Intra	YWHAB	P31946	ALS2	Homo sapiens	A0A0S2Z5Q7	Validated Y2H	32814053
Intra	YWHAB	P31946	ALS2	Homo sapiens	A0A0S2Z5Q7	Y2H Array	32814053
Intra	YWHAB	P31946	ALS2	Homo sapiens	A0A0S2Z5Q7	Y2H Pooling	32814053
Intra	YWHAB	P31946	SPG11	Homo sapiens	Q96JI7	Pull Down	36096339
Intra	YWHAB	P31946	MAP3K3	Homo sapiens	Q99759	Anti Tag CoIP	36931259
Intra	YWHAB	P31946	MAP3K3	Homo sapiens	Q99759	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	HDAC4	Homo sapiens	P56524	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	HDAC4	Homo sapiens	P56524	BioID	36931259
Intra	YWHAB	P31946	HDAC4	Homo sapiens	P56524	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	YWHAE	Homo sapiens	P62258	BioID	36931259
Intra	YWHAB	P31946	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	36931259
Intra	YWHAB	P31946	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	35271311
Intra	YWHAB	P31946	YWHAE	Homo sapiens	P62258	SLCA	17085597
Intra	YWHAB	P31946	YWHAE	Homo sapiens	P62258	Y2H Pooling	20936779
Intra	YWHAB	P31946	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	35271311
Intra	YWHAB	P31946	YWHAG	Homo sapiens	P61981	SLCA	17085597
Intra	YWHAB	P31946	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	35271311
Intra	YWHAB	P31946	YWHAQ	Homo sapiens	P27348	SLCA	17085597
Intra	YWHAB	P31946	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	BRAF	Homo sapiens	P15056	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	BRAF	Homo sapiens	P15056	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	BRAF	Homo sapiens	P15056	BioID	36931259
Intra	YWHAB	P31946	BRAF	Homo sapiens	P15056	Anti Bait CoIP	17353931
Intra	YWHAB	P31946	ZNF395	Homo sapiens	Q9H8N7	CoIP	17531190
Intra	YWHAB	P31946	ZNF395	Homo sapiens	Q9H8N7	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	DACT1	Homo sapiens	Q9NYF0	Y2H	21262972
Intra	YWHAB	P31946	DACT1	Homo sapiens	Q9NYF0	Anti Tag CoIP	21262972
Intra	YWHAB	P31946	DACT1	Homo sapiens	Q9NYF0	Anti Bait CoIP	21262972
Intra	YWHAB	P31946	TSC2	Homo sapiens	P49815	Pull Down	12438239
Intra	YWHAB	P31946	TSC2	Homo sapiens	P49815	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	TSC2	Homo sapiens	P49815	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	TSC2	Homo sapiens	P49815	BioID	36931259
Intra	YWHAB	P31946	TSC2	Homo sapiens	P49815	Anti Bait CoIP	17353931
Intra	YWHAB	P31946	TSC2	Homo sapiens	P49815	Anti Tag CoIP	35271311
Intra	YWHAB	P31946	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	YWHAB	P31946	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	YWHAB	P31946	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	YWHAB	P31946	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	YWHAB	P31946	MAP3K5	Homo sapiens	Q99683	Anti Tag CoIP	35271311
Intra	YWHAB	P31946	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	16959763
Intra	YWHAB	P31946	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	36931259
Intra	YWHAB	P31946	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	MARK2	Homo sapiens	Q7KZI7	Anti Tag CoIP	35271311
Intra	YWHAB	P31946	CBL	Homo sapiens	P22681	Anti Tag CoIP	36931259
Intra	YWHAB	P31946	CBL	Homo sapiens	P22681	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	CBL	Homo sapiens	P22681	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	CBL	Homo sapiens	P22681	Biochemical	11697890
Intra	YWHAB	P31946	LRRK2	Homo sapiens	Q5S007	Protein Array	24947832
Intra	YWHAB	P31946	SRPK2	Homo sapiens	P78362	CoIP	19592491
Intra	YWHAB	P31946	SRPK2	Homo sapiens	P78362	Protein Kinase Assay	23602568
Cross	YWHAB	P31946	Zfp36	Mus musculus	P22893	CoIP	14688255
Cross	YWHAB	P31946	Rnd3	Mus musculus	P61588	Anti Tag CoIP	23622247
Cross	YWHAB	P31946	Rnd3	Mus musculus	P61588	Pull Down	23622247
Intra	YWHAB	P31946	BAD	Homo sapiens	Q92934	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	BAD	Homo sapiens	Q92934	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	BAD	Homo sapiens	Q92934	Anti Tag CoIP	36931259
Intra	YWHAB	P31946	MARK3	Homo sapiens	P27448	Anti Tag CoIP	35271311
Intra	YWHAB	P31946	MARK3	Homo sapiens	P27448	Anti Bait CoIP	17353931
Intra	YWHAB	P31946	MARK3	Homo sapiens	P27448	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	MARK3	Homo sapiens	P27448	Anti Tag CoIP	36931259
Intra	YWHAB	P31946	MARK3	Homo sapiens	P27448	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	MARK3	Homo sapiens	P27448	BioID	36931259
Cross	YWHAB	P31946	Gem	Mus musculus	P55041	Pull Down	15860732
Cross	YWHAB	P31946	Gem	Mus musculus	P55041	Pull Down	14701738
Intra	YWHAB	P31946	AKT1S1	Homo sapiens	Q96B36	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	AKT1S1	Homo sapiens	Q96B36	Pull Down	18372248
Intra	YWHAB	P31946	AKT1S1	Homo sapiens	Q96B36	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	AKT1S1	Homo sapiens	Q96B36	Anti Tag CoIP	36931259
Intra	YWHAB	P31946	CBX4	Homo sapiens	O00257	Anti Bait CoIP	22078878
Intra	YWHAB	P31946	CBX4	Homo sapiens	O00257	BioID	36931259
Intra	YWHAB	P31946	GEM	Homo sapiens	P55040	Pull Down	14701738
Intra	YWHAB	P31946	CDC25A	Homo sapiens	P30304	Y2H	7644510
Intra	YWHAB	P31946	CDC25A	Homo sapiens	P30304	Pull Down	7644510
Intra	YWHAB	P31946	CDC25A	Homo sapiens	P30304	Anti Bait CoIP	7644510
Cross	YWHAB	P31946	Synpo2	Mus musculus	Q91YE8	Pull Down	15883195
Intra	YWHAB	P31946	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	YWHAB	P31946	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	YWHAB	P31946	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	YWHAB	P31946	ATXN1	Homo sapiens	P54253	BioID	36931259
Intra	YWHAB	P31946	CDC25C	Homo sapiens	P30307	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	CDC25C	Homo sapiens	P30307	Anti Tag CoIP	24255178
Intra	YWHAB	P31946	CDC25C	Homo sapiens	P30307	Anti Tag CoIP	35271311
Intra	YWHAB	P31946	CDC25C	Homo sapiens	P30307	Anti Tag CoIP	36931259
Intra	YWHAB	P31946	CHEK1	Homo sapiens	O14757	Anti Tag CoIP	35271311
Intra	YWHAB	P31946	CHEK1	Homo sapiens	O14757	Pull Down	20639859
Intra	YWHAB	P31946	GAB2	Homo sapiens	Q9UQC2	CoIP	19172738
Intra	YWHAB	P31946	GAB2	Homo sapiens	Q9UQC2	Anti Tag CoIP	33961781
Intra	YWHAB	P31946	GAB2	Homo sapiens	Q9UQC2	BioID	36931259

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant YWHAB Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P74439	14-3-3 beta Protein, Human (GST)	P31946 (M1-N246)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74440	14-3-3 beta Protein, Human	P31946 (M1-N246)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700304	14-3-3 beta Protein, Human (His)	P31946 (M1-N246)	≥ 95%, as determined by reducing SDS-PAGE.

YWHAB Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82204	14-3-3 beta Antibody (YA1949)	WB	Human, Rat
HY-P84258	14-3-3 beta Antibody (YA3955)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P84258A	14-3-3 beta Antibody (YA3955)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Chlamydia	Chlamydial Infection Chlamydia Trachomatis Infectious Disease Chlamydial Disease Chlamydia Infections
Eosinophilic Meningitis	Eosinophilic Meningoencephalitis Due To Angiostrongylus Cantonensis
Hyperinsulinemic Hypoglycemia, Familial, 5	Hyperinsulinism Due To Insr Deficiency HHF5 Familial Hyperinsulinemic Hypoglycemia 5 Hyperinsulinemic Hypoglycemia Due To Insr Deficiency Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency Congenital Hyperinsulinism Persistent Hyperinsulinemic Hypoglycemia Of Infancy Phhi Hyperinsulinemic Hypoglycemia Familial 5
Chronic Meningitis
Lymphogranuloma Venereum	Climatic Or Tropical Bubo Durand-Nicolas-Favre Disease Lymphogranuloma Inguinale Poradenitis Inguinale Strumous Bubo Lgv
Granuloma Inguinale	Donovanosis Pudendal Ulcer Granuloma Inguinale Tropicum Granuloma Pudendi Tropicum
Chromosome 17p13.3, Centromeric, Duplication Syndrome	Chromosome 17p13.3 Duplication Syndrome 17p13.3 Duplication Syndrome 17p13.3 Microduplication Syndrome Trisomy 17p13.3 Chromosome 17p13.3 Centromeric Duplication Syndrome Dup(17)(P13.3)

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS15940	YWHAB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19757	Ywhab Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26254	Ywhab Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	YWHAB	VGNC	VGNC:48508
Rattus norvegicus	YWHAB	RGD	RGD:61998
Mus musculus	YWHAB	MGD	MGI:1891917
Felis catus	YWHAB	VGNC	VGNC:67154
Macaca mulatta	YWHAB	VGNC	VGNC:78819
Bos taurus	YWHAB	VGNC	VGNC:37044
Others	YWHAB	NCBI