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Art. -Nr.: HY-15867

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Meayamycin B

Name: Meayamycin B
Brand: MedChemExpress
SKU: HY-15867
Availability: PreOrder

(Synonyms: (+)-Meayamycin B)

Meayamycin B ((+)-Meayamycin B) is a potent SF3B1 inhibitor. Meayamycin B upregulates the proapoptotic Mcl-1_S and downregulates Mcl-1_L at the pre-mRNA splicing level. Meayamycin B does not regulate the alternative splicing of Bcl-x. Meayamycin B and ABT-737 (HY-50907) synergistically causes Apoptosis. Meayamycin B exhibits anticancer activity against non-small cell lung cancer.

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CAS. Nr.: 1020210-12-1
Formel: C₃₁H₄₈N₂O₈
Molecular Weight:576.72

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Meayamycin B Chemical Structure

CAS. Nr.: 1020210-12-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Mcl-1

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.49 nM Compound: 96	Cytotoxicity against human HCT-116 cells assessed as inhibition in cell growth Cytotoxicity against human HCT-116 cells assessed as inhibition in cell growth	[PMID: 33974423]
HCT-116/VM46	IC₅₀	0.55 nM Compound: 96	Cytotoxicity against human HCT116/VM46 cells assessed as inhibition in cell growth Cytotoxicity against human HCT116/VM46 cells assessed as inhibition in cell growth	[PMID: 33974423]
L1210	IC₅₀	7.8 nM Compound: 96	Cytotoxicity against mouse L1210 cells assessed as inhibition in cell growth Cytotoxicity against mouse L1210 cells assessed as inhibition in cell growth	[PMID: 33974423]

Chemical Information

CAS. Nr. 1020210-12-1
Molecular Weight 576.72
Formel C₃₁H₄₈N₂O₈
SMILES

O[C@H]1[C@@]2(CC(C)(O[C@@H]1/C=C/C(C)=C/C[C@H]3[C@H](C[C@H]([C@H](O3)C)NC(/C=C\[C@H](C)OC(N4CCOCC4)=O)=O)C)C)CO2
Synonyms

(+)-Meayamycin B
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gao Y, et al. Chemical perturbation of Mcl-1 pre-mRNA splicing to induce apoptosis in cancer cells. ACS Chem Biol. 2013 May 17;8(5):895-900. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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Meayamycin B

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen