SMARCA2-IN-7
SMARCA2-IN-7 (compound 12), a dual inhibitor of BRM and BRG1 (IC50 < 0.005 for both), has an anti-tumor proliferation effect that inhibits BRG1-deleted SKMEL5 tumor proliferation with a cell proliferation activity AAC50 of 13 nM in SKMEL5. The cell proliferation activity AAC50 of KRT880 in H1299 cells was 42 nM.
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- CAS. Nr.: 2270879-43-9
- Formel: C11H9ClF2N4O2S
- Molecular Weight:334.73
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SBC-5 | EC50 |
>10 μM
Compound: 12
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Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay
Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay
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[PMID: 30339381] |
Chemical Information
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CAS. Nr. 2270879-43-9
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Molecular Weight 334.73
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Formel C11H9ClF2N4O2S
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SMILES
O=C(NC1=CC(C(F)F)=NS1)NC2=CC(Cl)=NC=C2CO
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SMARCA2-IN-7 Related Classifications
HY-161886 Related Classifications
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