Tacrolimus-13C,d2
Based on 1 publication(s) in Google Scholar
Tacrolimus-13C,d2 (FK506-13C,d2) is the 13C, deuterated-labeled Tacrolimus (HY-13756). Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.
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- Reinheit: 98.36%
- CAS. Nr.: 1356841-89-8
- Formel: C4313CH67D2NO12
- Molecular Weight:807.02
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tacrolimus-13C,d2
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Biologische Aktivität
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Macrolide |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1356841-89-8
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Unlabeled Cas 104987-11-3
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Appearance Solid
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Molecular Weight 807.02
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Formel C4313CH67D2NO12
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Color White to yellow
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SMILES
O=C(O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(C)=C/[C@H]2C[C@H]([C@@H](CC2)O)OC)[C@]3([H])CCCCN3C(C([C@]4([C@@H](C[C@@H]([C@@]([H])([C@H](C[C@H](C/C(C)=C/[C@H]1C/C=[13C]([2H])\[2H])C)OC)O4)OC)C)O)=O)=O
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Synonyms
FK506-13C,d2; Fujimycin-13C,d2; FR900506-13C,d2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
DMF : ≥ 30 mg/mL (37.17 mM)
Ethanol : ≥ 30 mg/mL (37.17 mM)
DMSO : ≥ 20 mg/mL (24.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (283 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Thomson AW, et al. Mode of action of Tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17(6):584-91. [Content Brief]
[2]. Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. J Inherit Metab Dis. 2016 Nov;39(6):877-886. [Content Brief]
[3]. Zhu H, et al. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF 1α expression in vivo. Mol Med Rep. 2014 Aug;10(2):585-92. [Content Brief]
[4]. Okada Y, et al. Tacrolimus ameliorates dextran sulfate sodium-induced colitis in mice: implication of interleukin-1β suppression. Biol Pharm Bull. 2011;34(12):1823-7. [Content Brief]
[6]. Soini L, et al. Molecular glues to stabilise protein-protein interactions. Curr Opin Chem Biol. 2022 Aug;69:102169. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / DMF / Ethanol | 1 mM | 1.2391 mL | 6.1956 mL | 12.3913 mL | 30.9782 mL |
| 5 mM | 0.2478 mL | 1.2391 mL | 2.4783 mL | 6.1956 mL | |
| 10 mM | 0.1239 mL | 0.6196 mL | 1.2391 mL | 3.0978 mL | |
| 15 mM | 0.0826 mL | 0.4130 mL | 0.8261 mL | 2.0652 mL | |
| 20 mM | 0.0620 mL | 0.3098 mL | 0.6196 mL | 1.5489 mL | |
| DMF / Ethanol | 25 mM | 0.0496 mL | 0.2478 mL | 0.4957 mL | 1.2391 mL |
| 30 mM | 0.0413 mL | 0.2065 mL | 0.4130 mL | 1.0326 mL |
Tacrolimus-13C,d2 Related Classifications
HY-13756S Related Classifications
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