2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 1-Palmitoyl-sn-glycero-3-phosphocholine

1-Palmitoyl-sn-glycero-3-phosphocholine  (Synonyms: 16:0 Lyso PC)

Cat. No.: HY-125783 Purity: 99.92%
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Handling Instructions Technical Support

1-Palmitoyl-sn-glycero-3-phosphocholine (16:0 Lyso PC) is an abundant lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the study of atherosclerosis.

For research use only. We do not sell to patients.

CAS No. : 17364-16-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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1-Palmitoyl-sn-glycero-3-phosphocholine Related Antibodies

Top Publications Citing Use of Products
Microbiological Assay

    1-Palmitoyl-sn-glycero-3-phosphocholine purchased from MedChemExpress. Usage Cited in: NPJ Biofilms Microbiomes. 2024 Oct 22;10(1):110.  [Abstract]

    Heatmap shows that metabolites enriched in new leaves can promote gut bacterial growth (n = 10). Four bacteria species were cultivated for 24 h in 1/2 LB liquid medium supplemented with 1000 nmol/mL of the five metabolites from three groups (LysoPC(1-Palmitoyl-sn-glycero-3-phosphocholine), Tyrosyl-Valine, Palmitoylcarnitine, Toxin-T2 and Citrulline) or H2O.

    View All Endogenous Metabolite Isoform Specific Products:

    View All Isoforms
    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    1-Palmitoyl-sn-glycero-3-phosphocholine (16:0 Lyso PC) is an abundant lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the study of atherosclerosis[1][2][3][4].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    1-Palmitoyl-sn-glycero-3-phosphocholine (125 μM, 2 h) induces superoxide overload on HUVECs by inhibiting SOD1. The levels of phosphoryl-ERK1/2 and eNOS were down-regulated[1].
    1-Palmitoyl-sn-glycero-3-phosphocholine (0.3, 1 μM, 24 h) can enhance the secretion of IL-6, IL-1β, IL-12 and TNF-α in LPS (HY-D1056)-stimulated M1 macrophages[2].
    1-Palmitoyl-sn-glycero-3-phosphocholine (10 μM, 24 h) increases TGF-β1 production and Foxp3 protein level in isolated human peripheral blood Treg cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    1-Palmitoyl-sn-glycero-3-phosphocholine Related Antibodies

    Cell Viability Assay[1]

    Cell Line: HUVECs
    Concentration: 50, 100, 125, 150 μM
    Incubation Time: 2 h
    Result: Inhibited cell viability in a concentration-dependent manner.

    Western Blot Analysis[1]

    Cell Line: HUVECs
    Concentration: 50, 100, 125, 150 μM
    Incubation Time: 0.5, 1, 2 h
    Result: Time-dependently decreased protein levels of eNOS and SOD1.
    In Vivo

    1-Palmitoyl-sn-glycero-3-phosphocholine (10 mg/kg, subcutaneous injection) enhances neutrophil function, bacterial clearance, and survival in a mouse model of sepsis[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Cecal ligation and puncture (CLP) mice[4]
    Dosage: 10 mg/kg
    Administration: s.c.
    Result: Increased bactericidal activity of neutrophils, but not macrophages, by enhancing H(2)O(2) production in neutrophils that ingested E. coli.
    Molecular Weight

    495.63

    Formula

    C24H50NO7P
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CCCCCCCCCCCCCCCC(OC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O)=O
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (100.88 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0176 mL 10.0882 mL 20.1763 mL
    5 mM 0.4035 mL 2.0176 mL 4.0353 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (100.88 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.92%

    SDS (396 KB)

    COA (240 KB) HNMR (261 KB) CNMR (237 KB) RP-HPLC (239 KB) MS (85 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.0176 mL 10.0882 mL 20.1763 mL 50.4409 mL
    5 mM 0.4035 mL 2.0176 mL 4.0353 mL 10.0882 mL
    10 mM 0.2018 mL 1.0088 mL 2.0176 mL 5.0441 mL
    15 mM 0.1345 mL 0.6725 mL 1.3451 mL 3.3627 mL
    20 mM 0.1009 mL 0.5044 mL 1.0088 mL 2.5220 mL
    25 mM 0.0807 mL 0.4035 mL 0.8071 mL 2.0176 mL
    30 mM 0.0673 mL 0.3363 mL 0.6725 mL 1.6814 mL
    40 mM 0.0504 mL 0.2522 mL 0.5044 mL 1.2610 mL
    50 mM 0.0404 mL 0.2018 mL 0.4035 mL 1.0088 mL
    60 mM 0.0336 mL 0.1681 mL 0.3363 mL 0.8407 mL
    80 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.6305 mL
    100 mM 0.0202 mL 0.1009 mL 0.2018 mL 0.5044 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    1-Palmitoyl-sn-glycero-3-phosphocholine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    1-Palmitoyl-sn-glycero-3-phosphocholine17364-16-816:0 Lyso PCEndogenous MetaboliteLysophosphatidylcholineHUVECsM1 macrophagesTreg cellsInhibitorinhibitorinhibit

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