1-Palmitoyl-sn-glycero-3-phosphocholine

Name: 1-Palmitoyl-sn-glycero-3-phosphocholine
Brand: MedChemExpress
SKU: HY-125783
Rating: 4.5 (1 reviews)

Cat. No.: HY-125783 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

1-Palmitoyl-sn-glycero-3-phosphocholine is an abundant lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the study of atherosclerosis.

For research use only. We do not sell to patients.

1-Palmitoyl-sn-glycero-3-phosphocholine Chemical Structure

CAS No. : 17364-16-8

Size	Price	Stock	Quantity
25 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 125	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 1-Palmitoyl-sn-glycero-3-phosphocholine:

1-Palmitoyl-sn-glycero-3-phosphocholine-d₉ Get quote
1-Palmitoyl-sn-glycero-3-phosphocholine-d₃₁ Get quote
1-Palmitoyl-sn-glycero-3-phosphocholine-d₄₉ Get quote
1-Palmitoyl-sn-glycero-3-phosphocholine-d₉-1 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

1-Palmitoyl-sn-glycero-3-phosphocholine (125 μM, 2 h) induces superoxide overload on HUVECs by inhibiting SOD1. The levels of phosphoryl-ERK1/2 and eNOS were down-regulated^[1].
1-Palmitoyl-sn-glycero-3-phosphocholine (0.3, 1 μM, 24 h) can enhance the secretion of IL-6, IL-1β, IL-12 and TNF-α in LPS (HY-D1056)-stimulated M1 macrophages^[2].
1-Palmitoyl-sn-glycero-3-phosphocholine (10 μM, 24 h) increases TGF-β1 production and Foxp3 protein level in isolated human peripheral blood Treg cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HUVECs
Concentration:	50, 100, 125, 150 μM
Incubation Time:	2 h
Result:	Inhibited cell viability in a concentration-dependent manner.

Western Blot Analysis^[1]

Cell Line:	HUVECs
Concentration:	50, 100, 125, 150 μM
Incubation Time:	0.5, 1, 2 h
Result:	Time-dependently decreased protein levels of eNOS and SOD1.

In Vivo

1-Palmitoyl-sn-glycero-3-phosphocholine (10 mg/kg, subcutaneous injection) enhances neutrophil function, bacterial clearance, and survival in a mouse model of sepsis^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Cecal ligation and puncture (CLP) mice^[4]
Dosage:	10 mg/kg
Administration:	s.c.
Result:	Increased bactericidal activity of neutrophils, but not macrophages, by enhancing H(2)O(2) production in neutrophils that ingested E. coli.

Molecular Weight

495.63

Formula

C₂₄H₅₀NO₇P

CAS No.

17364-16-8

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCC(OC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (100.88 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0176 mL	10.0882 mL	20.1763 mL
5 mM	0.4035 mL	2.0176 mL	4.0353 mL
10 mM	0.2018 mL	1.0088 mL	2.0176 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (100.88 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (240 KB) HNMR (290 KB) RP-HPLC (199 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Choi S, et al. Superoxide generated by lysophosphatidylcholine induces endothelial nitric oxide synthase downregulation in human endothelial cells. Cell Physiol Biochem. 2010;25(2-3):233-40. [Content Brief]

[2]. Qin X, et al. Lysophosphatidylcholine perpetuates macrophage polarization toward classically activated phenotype in inflammation. Cell Immunol. 2014 May-Jun;289(1-2):185-90. [Content Brief]

[3]. Hasegawa H, et al. Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-β production. Biochem Biophys Res Commun. 2011 Nov 25;415(3):526-31. [Content Brief]

[4]. Yan JJ, et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Nat Med. 2004 Feb;10(2):161-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.0176 mL	10.0882 mL	20.1763 mL	50.4409 mL
	5 mM	0.4035 mL	2.0176 mL	4.0353 mL	10.0882 mL
	10 mM	0.2018 mL	1.0088 mL	2.0176 mL	5.0441 mL
	15 mM	0.1345 mL	0.6725 mL	1.3451 mL	3.3627 mL
	20 mM	0.1009 mL	0.5044 mL	1.0088 mL	2.5220 mL
	25 mM	0.0807 mL	0.4035 mL	0.8071 mL	2.0176 mL
	30 mM	0.0673 mL	0.3363 mL	0.6725 mL	1.6814 mL
	40 mM	0.0504 mL	0.2522 mL	0.5044 mL	1.2610 mL
	50 mM	0.0404 mL	0.2018 mL	0.4035 mL	1.0088 mL
	60 mM	0.0336 mL	0.1681 mL	0.3363 mL	0.8407 mL
	80 mM	0.0252 mL	0.1261 mL	0.2522 mL	0.6305 mL
	100 mM	0.0202 mL	0.1009 mL	0.2018 mL	0.5044 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.