2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine 

Cat. No.: HY-W355700 Pureza: 98.95%
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Instrucciones de manejo Technical Support

1-oleoyl-sn-glycero-3-phosphoethanolamine (LysoPE 18:1) is a lysophosphatidylethanolamine molecule involved in phospholipid metabolism, targeting cell membrane receptors (such as G protein-coupled receptors) to regulate cell signaling pathways. 1-oleoyl-sn-glycero-3-phosphoethanolamine may activate mitogen-activated protein kinase (MAPK) signaling, promote cell migration, regulate inflammatory responses and lipid metabolism, and has both pro-inflammatory and anti-inflammatory activities. 1-oleoyl-sn-glycero-3-phosphoethanolamine is mainly used in the screening of biomarkers for metabolic diseases (such as non-alcoholic fatty liver disease and obesity), as well as the study of the mechanism of lysophospholipids in cell membrane homeostasis and signal transduction.

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1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine Estructura química

No. CAS : 89576-29-4

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Other Forms of 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine:

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine Related Antibodies

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Descripciòn

1-oleoyl-sn-glycero-3-phosphoethanolamine (LysoPE 18:1) is a lysophosphatidylethanolamine molecule involved in phospholipid metabolism, targeting cell membrane receptors (such as G protein-coupled receptors) to regulate cell signaling pathways. 1-oleoyl-sn-glycero-3-phosphoethanolamine may activate mitogen-activated protein kinase (MAPK) signaling, promote cell migration, regulate inflammatory responses and lipid metabolism, and has both pro-inflammatory and anti-inflammatory activities. 1-oleoyl-sn-glycero-3-phosphoethanolamine is mainly used in the screening of biomarkers for metabolic diseases (such as non-alcoholic fatty liver disease and obesity), as well as the study of the mechanism of lysophospholipids in cell membrane homeostasis and signal transduction[1][2].

In Vitro

The serum concentration of 1-oleoyl-sn-glycero-3-phosphoethanolamine in patients with non-alcoholic fatty liver disease (NAFLD) is significantly lower than that in the healthy control group. The total lysophosphatidylethanolamine (LysoPEs) concentrations in the simple steatosis (SS) and non-alcoholic steatohepatitis (NASH) groups are also lower than those in the healthy group, indicating that 1-oleoyl-sn-glycero-3-phosphoethanolamine can be used as a biomarker for NAFLD for disease identification and analysis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine Related Antibodies
Peso molecular

479.59

Fòrmula

C23H46NO7P
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](O)COP(OCCN)(O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad
In Vitro: 

DMSO : 2 mg/mL (4.17 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 2 mg/mL (4.17 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0851 mL 10.4256 mL 20.8511 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Pureza y Documentación

Purity: ≥99.0%

SDS (645 KB)

COA (239 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 2.0851 mL 10.4256 mL 20.8511 mL 52.1279 mL
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1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine89576-29-4Drug MetaboliteInhibitorinhibitorinhibit

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Nombre del producto:
1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine
Cat. No.:
HY-W355700
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