CLK1 - CDC like kinase 1 Gene

Also Known as CLK; STY; CLK/STY

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1195

About CLK1

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:200,853,009-200,864,658 (from NCBI)

This gene has 14 transcripts (splice variants), 185 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 96.5), lymph node (RPKM 51.9) and 25 other tissues.

Summary

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

CLK1 Products (5)

mRNA Protein Name
NM_001162407.1 NP_001155879.1 dual specificity protein kinase CLK1 isoform 2
NM_004071.4 NP_004062.2 dual specificity protein kinase CLK1 isoform 1
NR_027856.2
NR_027855.2
NM_001024646.1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10480872 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of RNA splicing IMP
IMP: Inferred from mutant phenotype
19168442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (161 - 477)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 484 a.a.
Protein Preferred Names Protein Names

dual specificity protein kinase CLK1

  • CDC28/CDC2-like kinase

  • protein tyrosine kinase STY

CLK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLK1 P49759 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
CLK1 P49759 PDE9A Homo sapiens O76083
Validated Y2H
25416956
Intra
CLK1 P49759 PDE9A Homo sapiens O76083
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

CLK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811058 CLK1 Antibody WB, IHC-P, ICC/IF Human, Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (53)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15338 TG003 Inhibitor 99.57% Unkown
HY-115470 CLK-IN-T3 Inhibitor 99.78% Unkown
HY-112296 T025 99.64% Unkown
HY-15951 ML167 Inhibitor 98.62% Unkown
HY-103082 CLK1-IN-1 Inhibitor 98.55% Unkown
HY-152219 CLK1-IN-2 Inhibitor 98.15% Unkown
HY-12828 KH-CB19 Inhibitor 99.31% Unkown
HY-103647 K00546 Inhibitor 99.48% Unkown
HY-155723 Leucettinib-92 Inhibitor 98.54% Unkown
HY-153708 SGC-CLK-1 Inhibitor 99.12% Unkown
HY-146221 Dyrk1A-IN-5 Inhibitor 98.06% Unkown
HY-123600 SRI-29329 Inhibitor 99.14% Unkown
HY-125290 MU1210 Inhibitor 99.50% Unkown
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-149262 CLK1-IN-3 98.54% Unkown
HY-P10100 RS Repeat peptide 98.89% Unkown
HY-122631 TG693 99.95% Unkown
HY-12828A KH-CB20 Inhibitor 99.80% Unkown
HY-131978 DB18 Inhibitor 99.15% Unkown
HY-113825 CLK1/2-IN-1 Inhibitor 99.87% Unkown
HY-400528 CLK1-IN-4 Inhibitor 99.75% Unkown
HY-15338A (E/Z)-TG003 Inhibitor 99.9% Unkown
HY-179177 AO-365/43472821 Inhibitor 99.94% Unkown
HY-183068 AP4-43 Inhibitor 99.76% Unkown
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor 98.67% Unkown
HY-131909 CJ-2360 Inhibitor / Unkown
HY-113670 CLK1/2-IN-2 Inhibitor 99.31% Unkown
HY-113831 CLK1/2-IN-3 Inhibitor / Unkown
HY-125202 KuWal151 Inhibitor / Unkown
HY-146335 CLK1/4-IN-1 Inhibitor / Unkown
HY-146586 Haspin-IN-1 Inhibitor / Unkown
HY-146587 Haspin-IN-2 Inhibitor / Unkown
HY-157995 Dyrk1A-IN-7 Inhibitor / Unkown
HY-176884 CDD-2110 Inhibitor / Unkown
HY-176885 CDD-2211 Inhibitor / Unkown
HY-176885A CDD-2212 Inhibitor / Unkown
HY-177416 MU1787 Inhibitor 99.84% Unkown
HY-182238 HPK1-IN-69 / Unkown
HY-182957 MNK/PIM-IN-2 / Unkown
HY-183831 GPS167 / Unkown
HY-184276 CLK1-IN-5 Inhibitor / Unkown
HY-184447 RN193 Inhibitor / Unkown
HY-E70691 CLK1 Recombinant Human Active Protein Kinase / Unkown
HY-N17356 Atalaphyllidine Inhibitor / Unkown
HY-RS02353 CDK11B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02814 CLK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02815 Clk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02816 Clk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03004 COLEC11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03043 COQ7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W409652 CLK1/4-IN-2 Inhibitor / Unkown
HY-RS18468 Coq7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18721 Colec11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLK1 MGD MGI:107403
Rattus norvegicus CLK1 RGD RGD:1311469
Felis catus CLK1 VGNC VGNC:60963
Bos taurus CLK1 VGNC VGNC:27448
Macaca mulatta CLK1 VGNC VGNC:71258
Canis familiaris CLK1 VGNC VGNC:39346
Others CLK1 NCBI