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Cat. No.: HY-184276

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CLK1-IN-5

CLK1-IN-5 is a potent and selective CLK1 inhibitor with an IC₅₀ of 23 nM. CLK1-IN-5 can be used in the research of cancer and Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₁₃H₁₄N₄OS
Molecular Weight:274.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CLK1-IN-5 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

CLK1-IN-5 is a potent and selective CLK1 inhibitor with an IC₅₀ of 23 nM. CLK1-IN-5 can be used in the research of cancer and Alzheimer's disease^[1].

All CDK Isoforms :

In Vitro

CLK1-IN-5 (Compound 2) potently inhibits purified mouse CLK1 protein, with an IC₅₀ of 23 nM and a ligand efficiency of 0.56^[1].
CLK1-IN-5 (2 h) binds to ectopically expressed CLK1, DYRK1A, and DYRK2 in HEK293T cells, with EC₅₀ values of 3443, 8414, and > 10000 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 274.34
Formula C₁₃H₁₄N₄OS
SMILES

CCCNC1=NN2C(S1)=NC=C2C3=CC=C(O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bourg S, et al.. Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships. European journal of medicinal chemistry. 2026 Oct 05;315:118977. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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CLK1-IN-5

All CDK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CLK1-IN-5 Related Classifications

HY-184276 Related Classifications