2. Cell Cycle/DNA Damage
  3. CDK
  4. CLK1-IN-5

CLK1-IN-5 is a potent and selective CLK1 inhibitor with an IC50 of 23 nM. CLK1-IN-5 can be used in the research of cancer and Alzheimer's disease.

For research use only. We do not sell to patients.

CLK1-IN-5

CLK1-IN-5 Chemical Structure

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CLK1-IN-5 Related Antibodies

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Description

CLK1-IN-5 is a potent and selective CLK1 inhibitor with an IC50 of 23 nM. CLK1-IN-5 can be used in the research of cancer and Alzheimer's disease[1].

In Vitro

CLK1-IN-5 (Compound 2) potently inhibits purified mouse CLK1 protein, with an IC50 of 23 nM and a ligand efficiency of 0.56[1].
CLK1-IN-5 (2 h) binds to ectopically expressed CLK1, DYRK1A, and DYRK2 in HEK293T cells, with EC50 values of 3443, 8414, and > 10000 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CLK1-IN-5 Related Antibodies
Molecular Weight

274.34

Formula

C13H14N4OS
SMILES

CCCNC1=NN2C(S1)=NC=C2C3=CC=C(O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CLK1-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CLK1-IN-5CDKCyclin dependent kinaseLeu244alzheimer's diseaseDYRK1ADYRK2CLK1cancermurine CLK1 proteinHEK293T cellsInhibitorinhibitorinhibit

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CLK1-IN-5
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