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Cat. No.: HY-184276

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CLK1-IN-5

CLK1-IN-5 is a potent and selective CLK1 inhibitor with an IC₅₀ of 23 nM. CLK1-IN-5 can be used in the research of cancer and Alzheimer's disease.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₁₃H₁₄N₄OS
Masse moléculaire:274.34

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CLK1-IN-5 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

CLK1-IN-5 is a potent and selective CLK1 inhibitor with an IC₅₀ of 23 nM. CLK1-IN-5 can be used in the research of cancer and Alzheimer's disease^[1].

Voir tous les produits spécifiques à Isoform CDK :

In Vitro

CLK1-IN-5 (Compound 2) potently inhibits purified mouse CLK1 protein, with an IC₅₀ of 23 nM and a ligand efficiency of 0.56^[1].
CLK1-IN-5 (2 h) binds to ectopically expressed CLK1, DYRK1A, and DYRK2 in HEK293T cells, with EC₅₀ values of 3443, 8414, and > 10000 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

Masse moléculaire 274.34
Formule C₁₃H₁₄N₄OS
SMILES

CCCNC1=NN2C(S1)=NC=C2C3=CC=C(O)C=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Bourg S, et al.. Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships. European journal of medicinal chemistry. 2026 Oct 05;315:118977. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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