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Cat. No.: HY-184276

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CLK1-IN-5

CLK1-IN-5 is a potent and selective CLK1 inhibitor with an IC₅₀ of 23 nM. CLK1-IN-5 can be used in the research of cancer and Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₁₃H₁₄N₄OS
Molecular Weight:274.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CLK1-IN-5 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CLK1-IN-5 is a potent and selective CLK1 inhibitor with an IC₅₀ of 23 nM. CLK1-IN-5 can be used in the research of cancer and Alzheimer's disease^[1].

All CDK Isoforms :

In Vitro

CLK1-IN-5 (Compound 2) potently inhibits purified mouse CLK1 protein, with an IC₅₀ of 23 nM and a ligand efficiency of 0.56^[1].
CLK1-IN-5 (2 h) binds to ectopically expressed CLK1, DYRK1A, and DYRK2 in HEK293T cells, with EC₅₀ values of 3443, 8414, and > 10000 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 274.34
Formula C₁₃H₁₄N₄OS
SMILES

CCCNC1=NN2C(S1)=NC=C2C3=CC=C(O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology Animals and Diseases

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bourg S, et al.. Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships. European journal of medicinal chemistry. 2026 Oct 05;315:118977. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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