1. Cell Cycle/DNA Damage
  2. CDK
  3. CLK1-IN-2

CLK1-IN-2 

Cat. No.: HY-152219
Handling Instructions

CLK1-IN-2 is metabolically stable Clk1 inhibitor. CLK1-IN-2 has selectivity for Clk1 with an IC50 value of 1.7 nM. CLK1-IN-2 can be used for the research of tumour, Duchenne's muscular dystrophy and viral infections such as HIV-1 and influenza.

For research use only. We do not sell to patients.

CLK1-IN-2 Chemical Structure

CLK1-IN-2 Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CLK1-IN-2 is metabolically stable Clk1 inhibitor. CLK1-IN-2 has selectivity for Clk1 with an IC50 value of 1.7 nM. CLK1-IN-2 can be used for the research of tumour, Duchenne's muscular dystrophy and viral infections such as HIV-1 and influenza[1].

IC50 & Target

IC50: 1.7 nM (Clk1)[1].

In Vitro

CLK1-IN-2 (Compound 27a) has selectivity for Clk1 with an IC50 value of 1.7 nM[1].
CLK1-IN-2 shows long metabolic half-lives of 6.4 h[1].
CLK1-IN-2exhibits a GI50 of 3.4 μM in T24 cancer cells[1].
CLK1-IN-2 shows a cellular Ki valiue of 0.051 μM in NanoBRET cellular Clk1 engagement assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: Human dermal fibroblasts
Concentration: 15 μM
Incubation Time: 2 days
Result: Not affected the proliferation of normal human cells such as fibroblasts.
Molecular Weight

367.25

Formula

C16H12Cl2N2O2S

SMILES

O=C(C1=CC2=CC(OC)=CC=C2S1)NNC3=CC(Cl)=CC(Cl)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CLK1-IN-2
Cat. No.:
HY-152219
Quantity:
MCE Japan Authorized Agent: