CLK1-IN-2
Based on 1 Customer Validation
CLK1-IN-2 is metabolically stable Clk1 inhibitor. CLK1-IN-2 has selectivity for Clk1 with an IC50 value of 1.7 nM. CLK1-IN-2 can be used for the research of tumour, Duchenne's muscular dystrophy and viral infections such as HIV-1 and influenza.
For research use only. We do not sell to patients.
- Purity: 98.15%
- CAS No.: 3029431-68-0
- Formula: C16H12Cl2N2O2S
- Molecular Weight:367.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 1.7 nM (Clk1)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T-24 | GI50 |
3.4 μM
Compound: 27a
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Antiproliferative activity against human T24 cells assessed as cell growth inhibition incubated for 3 days by MTT assay
Antiproliferative activity against human T24 cells assessed as cell growth inhibition incubated for 3 days by MTT assay
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[PMID: 36580731] |
CLK1-IN-2 (Compound 27a) has selectivity for Clk1 with an IC50 value of 1.7 nM[1].
CLK1-IN-2 shows long metabolic half-lives of 6.4 h[1].
CLK1-IN-2exhibits a GI50 of 3.4 μM in T24 cancer cells[1].
CLK1-IN-2 shows a cellular Ki valiue of 0.051 μM in NanoBRET cellular Clk1 engagement assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human dermal fibroblasts
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Concentration:15 μM
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Incubation Time:2 days
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Result:Not affected the proliferation of normal human cells such as fibroblasts.
Chemical Information
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CAS No. 3029431-68-0
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Appearance Solid
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Molecular Weight 367.25
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Formula C16H12Cl2N2O2S
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Color Off-white to light yellow
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SMILES
O=C(C1=CC2=CC(OC)=CC=C2S1)NNC3=CC(Cl)=CC(Cl)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (272.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7229 mL | 13.6147 mL | 27.2294 mL | 68.0735 mL |
| 5 mM | 0.5446 mL | 2.7229 mL | 5.4459 mL | 13.6147 mL | |
| 10 mM | 0.2723 mL | 1.3615 mL | 2.7229 mL | 6.8074 mL | |
| 15 mM | 0.1815 mL | 0.9076 mL | 1.8153 mL | 4.5382 mL | |
| 20 mM | 0.1361 mL | 0.6807 mL | 1.3615 mL | 3.4037 mL | |
| 25 mM | 0.1089 mL | 0.5446 mL | 1.0892 mL | 2.7229 mL | |
| 30 mM | 0.0908 mL | 0.4538 mL | 0.9076 mL | 2.2691 mL | |
| 40 mM | 0.0681 mL | 0.3404 mL | 0.6807 mL | 1.7018 mL | |
| 50 mM | 0.0545 mL | 0.2723 mL | 0.5446 mL | 1.3615 mL | |
| 60 mM | 0.0454 mL | 0.2269 mL | 0.4538 mL | 1.1346 mL | |
| 80 mM | 0.0340 mL | 0.1702 mL | 0.3404 mL | 0.8509 mL | |
| 100 mM | 0.0272 mL | 0.1361 mL | 0.2723 mL | 0.6807 mL |
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