2. Gene
  3. PDE9A - phosphodiesterase 9A Gene

PDE9A - phosphodiesterase 9A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HSPDE9A2

Gene ID: 5152 | Gene type: protein coding

About PDE9A

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,653,621-42,775,509 (from NCBI)

This gene has 28 transcripts (splice variants), 192 orthologues and 20 paralogues. Broad expression in colon (RPKM 12.5), prostate (RPKM 9.8) and 17 other tissues.

Summary

The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PDE9A Products(24)

mRNA Protein Name
NM_001001576.2 NP_001001576.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j
XM_011529598.3 XP_011527900.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1
NM_001001584.3 NP_001001584.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001583.2 NP_001001583.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform o
NM_001001568.2 NP_001001568.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform c
NM_001001573.2 NP_001001573.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001572.2 NP_001001572.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001567.2 NP_001001567.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform b
NM_001001569.2 NP_001001569.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform d
XM_011529600.3 XP_011527902.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2
NM_001001581.2 NP_001001581.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform m
NM_001001575.2 NP_001001575.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform i
NM_001001578.2 NP_001001578.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform l
NM_001001585.2 NP_001001585.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
XM_017028366.2 XP_016883855.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3
NM_002606.3 NP_002597.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a
NM_001001579.2 NP_001001579.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001571.2 NP_001001571.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform f
NM_001001582.2 NP_001001582.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform n
NM_001001577.2 NP_001001577.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform k
NM_001001570.2 NP_001001570.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform e
NM_001315533.2 NP_001302462.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform p
NM_001001574.2 NP_001001574.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform h
NM_001001580.2 NP_001001580.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j

PDE9A Protein Structure

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (311 - 534)

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  • 593 a.a.
Protein Preferred Names Protein Names

high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

CGMP-specific 3',5'-cyclic phosphodiesterase type 9

phosphodiesterase PDE9A21

Recombinant PDE9A Proteins

Cat. No. Product Name Accession Purity
HY-P75962 PDE9A Protein, Human (sf9, His-GST) O76083-2 (M1-A533) ≥95%
HY-P75963 PDE9A Protein, Human (His) O76083-2 (P181-K506) ≥95%

Related Diseases

Diseases Alias
Cecum Adenocarcinoma

Cecal Adenocarcinoma

Adenocarcinoma Of Cecum
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Congenital Anomaly Of Heart

Heart Defect

Heart Malformation

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Transient Global Amnesia

Amnesia, Transient Global
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15441 Edelinontrine Inhibitor 98.74% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-104028 BAY 73-6691 Inhibitor 99.84% Unkown
HY-12788 PF-04449613 Inhibitor 99.83% Unkown
HY-126137 PDE9-IN-1 Inhibitor 99.70% Unkown
HY-12788A (S)-PF-04449613 Inhibitor 99.85% Unkown
HY-152106 BAY-7081 Inhibitor / Unkown
HY-104028B (S)-BAY 73-6691 99.51% Unkown
HY-RS10246 PDE9A Human Pre-designed siRNA Set A / Unkown
HY-RS10247 Pde9a Mouse Pre-designed siRNA Set A / Unkown
HY-RS10248 Pde9a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDE9A VGNC VGNC:75925
Bos taurus PDE9A VGNC VGNC:32688
Rattus norvegicus PDE9A RGD RGD:621035
Mus musculus PDE9A MGD MGI:1277179
Felis catus PDE9A VGNC VGNC:68767
Canis familiaris PDE9A VGNC VGNC:44367
Others PDE9A NCBI