SGPP2 - sphingosine-1-phosphate phosphatase 2 Gene

Also Known as SPP2; SPPase2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 130367

About SGPP2

Cytogenetic location: 2q36.1 Genomic coordinates (GRCh38): 2:222,423,988-222,562,621 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 13.7), esophagus (RPKM 12.0) and 18 other tissues.

Summary

The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

SGPP2 Products (3)

mRNA Protein Name
NM_001320833.2 NP_001307762.1 sphingosine-1-phosphate phosphatase 2 isoform b
NM_001320834.2 NP_001307763.1 sphingosine-1-phosphate phosphatase 2 isoform b
NM_152386.4 NP_689599.2 sphingosine-1-phosphate phosphatase 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sphingosine-1-phosphate phosphatase activity IDA
IDA: Inferred from direct assay
12411432 GOA
enables sphingosine-1-phosphate phosphatase activity IMP
IMP: Inferred from mutant phenotype
27059959 GOA
Biological Process GO Annotation Evidence References Source
involved in sphingosine metabolic process IDA
IDA: Inferred from direct assay
12411432 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12411432 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGPP2 Protein Structure

PAP2

PAP2: PAP2 superfamily (121 - 233)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
Protein Preferred Names Protein Names

sphingosine-1-phosphate phosphatase 2

  • sphingosine 1-phosphate phosphohydrolase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12811 SGPP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22803 Sgpp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29317 Sgpp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SGPP2 RGD RGD:1565739
Canis familiaris SGPP2 VGNC VGNC:57395
Bos taurus SGPP2 VGNC VGNC:54481
Felis catus SGPP2 VGNC VGNC:65084
Mus musculus SGPP2 MGD MGI:3589109
Macaca mulatta SGPP2 VGNC VGNC:77278
Others SGPP2 NCBI