1029227-48-2
Chemical Structure
Coibamide A
- CAS No.: 1029227-48-2
- Formula:C65H110N10O16
- Molecular Weight:1287.63
InChIKey: LVHKHLZPRPTQJG-SPZMMXJESA-N
SMILES: CC(C)[C@H](N(C)C)C(O[C@H](C(C)C)C(N(C)[C@@H](COC)C(N(C)[C@@H](CC(C)C)C(N([C@@H]1C(N([C@H](C(N([C@@](C(N[C@H](C(N([C@H](C(N[C@H](C(N([C@@H](C(O[C@@H]1C)=O)C)C)=O)CC2=CC=C(C=C2)OC)=O)CC(C)C)C)=O)C)=O)([H])[C@@H](C)CC)C)=O)COC)C)=O)C)=O)=O)=O)=O
Biological Activity: Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts[1][2].
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Coibamide A | Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts. | |||||||||||||||||||||
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References
- [1]. Jeffrey D Serrill, et al. Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts. Invest New Drugs. 2016 Feb;34(1):24-40. [Content Brief]
- [2]. Andrew M Hau, et al. Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells. PLoS One. 2013 Jun 6;8(6):e65250. [Content Brief]
