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Cat. No.: HY-N21698

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Uralodin B

Uralodin B is a naturally occurring polycyclic polyprenylated acylphloroglucinol (PPAP) and is the C (30)-epimer of Uralodin C. It is found in the aerial parts of Hypericum henryi subsp. uraloides. Uralodin B exhibits cytotoxic activity against SGC7901 and HL-60 tumor cells. It is useful for research related to PPAP natural products and tumor cytotoxicity.

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CAS No.: 1253206-38-0
Formule: C₃₈H₅₀O₅
Masse moléculaire:586.80

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Uralodin B Chemical Structure

CAS No.: 1253206-38-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC50	21.8 μM	Cytotoxic activity against human HL-60 promyelocytic leukemia cells assessed by MTT assay after 48 h of continuous exposure. Cytotoxic activity against human HL-60 promyelocytic leukemia cells assessed by MTT assay after 48 h of continuous exposure.	20087990
SGC-7901	IC50	63.7 μM	Cytotoxic activity against human SGC7901 gastric carcinoma cells assessed by MTT assay after 48 h of continuous exposure. Cytotoxic activity against human SGC7901 gastric carcinoma cells assessed by MTT assay after 48 h of continuous exposure.	20087990
HepG2	IC50	171.0 μM	Cytotoxic activity against human HepG2 hepatocellular carcinoma cells assessed by MTT assay after 48 h of continuous exposure. Cytotoxic activity against human HepG2 hepatocellular carcinoma cells assessed by MTT assay after 48 h of continuous exposure.	20087990
K562	IC50	171.0 μM	Cytotoxic activity against human K562 chronic myelogenous leukemia cells assessed by MTT assay after 48 h of continuous exposure. Cytotoxic activity against human K562 chronic myelogenous leukemia cells assessed by MTT assay after 48 h of continuous exposure.	20087990

In Vitro

Uralodin B (0.064-40 μM; 48 h) exerts modest cytotoxic effects against HL-60 and SGC7901 cells with IC₅₀ values of 21.8 μM and 63.7 μM, respectively, while showing weak activity against HepG2 and K562 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HepG2 human hepatocellular carcinoma cells, SGC7901 human gastric carcinoma cells, HL-60 human promyelocytic leukemia cells, K562 human chronic myelogenous leukemia cells
Concentration:

0.064, 0.32, 1.6, 8, 40 μM
Incubation Time:

48 h
Result:

Exhibited the most potent cytotoxic activity against HL-60 cells, with an IC50 of 21.8 μM.
Showed modest cytotoxicity against SGC7901 cells, with an IC50 of 63.7 μM.
Showed minimal cytotoxic activity against HepG2 and K562 cell lines, with IC50 values of 171.0 μM for both cell lines.

Chemical Information

CAS No. 1253206-38-0
Masse moléculaire 586.80
Formule C₃₈H₅₀O₅
SMILES

O=C(C1=CC=CC=C1)[C@@]23[C@@](C)([C@H](C[C@@](C2=O)(C4=C(C[C@@H](O4)C(C)(O)C)C3=O)C/C=C(C)\C)C/C=C(C)\C)CC/C=C(C)/C
Structure Classification
- Terpenoids
- Other Monoterpenes
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Chen XQ, et al. Polycyclic polyprenylated acylphloroglucinols and chromone O-glucosides from Hypericum henryi subsp. uraloides. Chemistry & biodiversity. 2010 Jan;7(1):196-204.

[2]. Hu JW, et al. Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron. Journal of natural products. 2018 Nov 26;81(11):2348-2356.

Calculators

Calculateur de molarité

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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