CP-447697

Cat. No.: HY-112199 Purity: 99.70%: Data Sheet
COA

SDS
Handling Instructions
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CP-447697 is a lipophilic C5a receptor antagonist with an IC₅₀ value of 31 nM. CP-447697 can be used for the research of inflammation.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CP-447697 화학구조

CAS No. : 1092847-21-6

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

CP-447697 is a lipophilic C5a receptor antagonist with an IC₅₀ value of 31 nM. CP-447697 can be used for the research of inflammation^[1].

IC₅₀ & Target

IC50: 31 nM (C5a receptor)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Neutrophil	IC₅₀	250 nM Compound: 2, CP-447697	Inhibition of C5a-induced elastase release in human neutrophils measured by cleavage of chromogenic MeO-Suc-Ala-Ala-ProlVal-pNA Inhibition of C5a-induced elastase release in human neutrophils measured by cleavage of chromogenic MeO-Suc-Ala-Ala-ProlVal-pNA	[PMID: 18809326]
U-937	IC₅₀	31 nM Compound: 2, CP-447697	Displacement of [125I]r-hC5a from C5a receptor in cAMP differentiated human U937 cells Displacement of [125I]r-hC5a from C5a receptor in cAMP differentiated human U937 cells	[PMID: 18809326]

분자량

554.05

화학식

C₂₉H₂₆ClF₂N₃O₂S

CAS No.

1092847-21-6

Appearance

Solid

Color

White to off-white

SMILES

ClC(C=C1)=CC=C1CCN(C(C2=CSC3=C2C=CC=C3)=O)C4CCN(C(NC5=CC=C(F)C=C5F)=O)CC4

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도

In Vitro:

DMSO : 125 mg/mL (225.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8049 mL	9.0245 mL	18.0489 mL
5 mM	0.3610 mL	1.8049 mL	3.6098 mL
10 mM	0.1805 mL	0.9024 mL	1.8049 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.70%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (258 KB) HNMR (280 KB) LCMS (272 KB)

Handling Instructions (2659 KB)

References

[1]. Blagg J, et al. Small, non-peptide C5a receptor antagonists: part 1. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5601-4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8049 mL	9.0245 mL	18.0489 mL	45.1223 mL
	5 mM	0.3610 mL	1.8049 mL	3.6098 mL	9.0245 mL
	10 mM	0.1805 mL	0.9024 mL	1.8049 mL	4.5122 mL
	15 mM	0.1203 mL	0.6016 mL	1.2033 mL	3.0082 mL
	20 mM	0.0902 mL	0.4512 mL	0.9024 mL	2.2561 mL
	25 mM	0.0722 mL	0.3610 mL	0.7220 mL	1.8049 mL
	30 mM	0.0602 mL	0.3008 mL	0.6016 mL	1.5041 mL
	40 mM	0.0451 mL	0.2256 mL	0.4512 mL	1.1281 mL
	50 mM	0.0361 mL	0.1805 mL	0.3610 mL	0.9024 mL
	60 mM	0.0301 mL	0.1504 mL	0.3008 mL	0.7520 mL
	80 mM	0.0226 mL	0.1128 mL	0.2256 mL	0.5640 mL
	100 mM	0.0180 mL	0.0902 mL	0.1805 mL	0.4512 mL

CP-447697 Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-4476971092847-21-6CP447697CP 447697Complement Systemlibrary screeninflammationlipophilicrapidly metabolizeInhibitorinhibitorinhibit

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CP-447697

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CP-447697 Related Antibodies

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Biological Activity

순도&문서

References

고객리뷰

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

CP-447697 Related Classifications

Keywords:

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고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

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