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Cat. No.: HY-184812

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CysLT1/2 receptor antagonist-1

CysLT1/2 receptor antagonist-1 is a dual CysLT1 and CysLT2 receptor antagonist with IC₅₀ values of 0.044 μM (CysLT1) and 0.17 μM (CysLT2). CysLT1/2 receptor antagonist-1 can be used for the research of bronchial asthma.

For research use only. We do not sell to patients.

CAS No.: 1637756-67-2
Formula: C₃₁H₃₄N₂O₇
Molecular Weight:546.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CysLT1/2 receptor antagonist-1 Chemical Structure

CAS No.: 1637756-67-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

CysLT₁

0.044 μM (IC₅₀)

CysLT₂

0.17 μM (IC₅₀)

All Leukotriene Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.044 μM Compound: 11b	Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay	[PMID: 25408836]
HEK293	IC₅₀	0.17 μM Compound: 11b	Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay	[PMID: 25408836]

In Vitro

CysLT1/2 receptor antagonist-1 (Compound 11b) antagonizes CysLT1 and CysLT2 receptors, with an IC₅₀ value of 0.044 μM against CysLT1 and 0.17 μM against CysLT2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1637756-67-2
Molecular Weight 546.61
Formula C₃₁H₃₄N₂O₇
SMILES

O=C(CCCCN1C2=C(OC(C1)C(O)=O)C(NC(C3=CC=C(C=C3)OCCCCC4=CC=CC=C4)=O)=CC=C2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Itadani S, et al. Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist. ACS Med Chem Lett. 2014 Oct 6;5(11):1230-4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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