1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. [D-Trp7,9,10]-Substance P TFA

[D-Trp7,9,10]-Substance P TFA 

Cat. No.: HY-P1375A
Handling Instructions

[D-Trp7,9,10]-Substance P TFA is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[D-Trp7,9,10]-Substance P TFA Chemical Structure

[D-Trp7,9,10]-Substance P TFA Chemical Structure

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Description

[D-Trp7,9,10]-Substance P TFA is a substance P analogue. Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors[1].

In Vitro

Substance P (SP)-related peptide, pGlu-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2, inhibits the activation of Gi or Go by M2 muscarinic cholinergic receptor (M2 mAChR) or of Gs by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1702.90

Formula

C₈₁H₁₀₆F₃N₂₁O₁₅S

Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Trp-Met-NH2

Sequence Shortening

RPKPQQWFWWM-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
[D-Trp7,9,10]-Substance P TFA
Cat. No.:
HY-P1375A
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