DBO-83 dihydrochloride

Name: DBO-83 dihydrochloride
Brand: MedChemExpress
SKU: HY-130432
Rating: 4.5 (0 reviews)

Cat. No.: HY-130432: Ficha de datos Instrucciones de manejo
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DBO-83 dihydrochloride is a brain-penetrant nicotinic acetylcholine receptor (nAChR) agonist. DBO-83 dihydrochloride activates peripheral nicotinic acetylcholine receptors to evoke non-stimulated ileum contractions. DBO-83 dihydrochloride shows antinociceptive and anti-amnesic activities.

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DBO-83 dihydrochloride Estructura química

No. CAS : 195211-53-1

Tamaño	Stock	Cantidad
1 mg	Obtener un presupuesto 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Obtener un presupuesto 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Obtener un presupuesto 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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Other Forms of DBO-83 dihydrochloride:

DBO-83 free base Obtener un presupuesto

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Descripciòn

In Vitro

DBO-83 dihydrochloride (10 µM) shows high selectivity for [³H]-cytisine-labeled nicotinic receptors, inhibiting 85% of binding at 10 µM with no activity against a panel of other receptor types^[1].
DBO-83 dihydrochloride constricts guinea pig isolated ileum fragments with an EC₅₀ of 3.05 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DBO-83 (1-20 mg/kg; i.p.; 5-7.5 µg per mouse; i.c.v.) dihydrochloride induces dose-dependent, centrally mediated antinociception in the mouse hot-plate tests^[1].
DBO-83 (5-20 mg/kg; s.c.) dihydrochloride induces dose-dependent antinociception in the mouse abdominal constriction test^[1].
DBO-83 (10-20 mg/kg; i.p.) dihydrochloride induces dose-dependent antinociception in the rat paw-pressure test, with a maximum paw pressure threshold of 104.6 g at 20 mg/kg i.p. measured 15 minutes after administration^[1].
DBO-83 (1-10 mg/kg; i.p.) dihydrochloride shows antiamnesic activity in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss albino mice in the hot-plate tests (male, 23-30 g)^[1]
Dosage:	1 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg (i.p.); 5 µg per mouse; 7.5 µg per mouse (i.c.v.)
Administration:	i.p.; i.c.v.
Result:	Produced a dose-dependent increase in licking latency, peaking 15-30 minutes after injection. Reached licking latencies of 32.3 sec at 15 minutes, 30.4 sec at 30 minutes, and 25.9 sec at 45 minutes at 10 mg/kg i.p..

Animal Model:	Amnesic mice^[2]
Dosage:	1, 5, 10 mg/kg
Administration:	i.p.
Result:	Prevented amnesia induced by Scopolamine (HY-N0296), Mecamylamine (HY-B1395A) and dihydro-β-erythroidine (HY-N10497).

Peso molecular

297.61

Fòrmula

C₁₀H₁₅Cl₃N₄

No. CAS

195211-53-1

SMILES

ClC1=CC=C(N=N1)N2CC(CC3)NC3C2.Cl.Cl

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Carla Ghelardini, et al. Antinociceptive profile of the new nicotinic agonist DBO-83. Drug development research. 40:,251-258.(1997)

[2]. Carla Ghelardini, et al. Antiamnesic Activity of the Nicotinic Agonist DBO-83 in Mice.Drug development research.