Ophiobolin A
Based on 1 Customer Validation
Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase, with an IC50 value of 9 μM. Ophiobolin A antimicrobial and anticancer activity.
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- Reinheit: 98.86%
- CAS. Nr.: 4611-05-6
- Formel: C25H36O4
- Molecular Weight:400.55
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Speicherung:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 9 μM (calmodulin-activated cyclic nucleotide phosphodiesterase)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
0.1 μM
Compound: Ophiobolin A
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Antiproliferative activity against human A549 cells by MTT assay
Antiproliferative activity against human A549 cells by MTT assay
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[PMID: 26341136] |
| A549 | IC50 |
50 ng/mL
Compound: 2
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 10395513] |
| B16-F10 | IC50 |
0.29 μM
Compound: 3
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Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 33074690] |
| Hs 683 | GI50 |
0.02 μM
Compound: Ophiobolin A
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Antiproliferative activity against human Hs683 cells by MTT assay
Antiproliferative activity against human Hs683 cells by MTT assay
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[PMID: 26341136] |
| HT-29 | IC50 |
50 ng/mL
Compound: 2
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Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
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[PMID: 10395513] |
| MCF7 | GI50 |
0.06 μM
Compound: Ophiobolin A
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Antiproliferative activity against human MCF7 cells by MTT assay
Antiproliferative activity against human MCF7 cells by MTT assay
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[PMID: 26341136] |
| P388 | IC50 |
25 ng/mL
Compound: 2
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 10395513] |
| Panel NCI-60 (60 carcinoma cell lines) | GI50 |
72 nM
Compound: 1
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Cytotoxicity against human NCI60 cells
Cytotoxicity against human NCI60 cells
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[PMID: 30765189] |
| SK-MEL-28 | GI50 |
0.05 μM
Compound: Ophiobolin A
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Antiproliferative activity against human SK-MEL-28 cells by MTT assay
Antiproliferative activity against human SK-MEL-28 cells by MTT assay
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[PMID: 26341136] |
| U-373MG ATCC | GI50 |
0.06 μM
Compound: Ophiobolin A
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Antiproliferative activity against human U373 cells by MTT assay
Antiproliferative activity against human U373 cells by MTT assay
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[PMID: 26341136] |
Chemical Information
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CAS. Nr. 4611-05-6
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Appearance Solid
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Molecular Weight 400.55
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Formel C25H36O4
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Color White to off-white
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SMILES
O=C/C1=C/C[C@]2([H])[C@@](CC[C@@]23O[C@@H](/C=C(C)\C)C[C@@H]3C)(C)C[C@@]4([H])[C@]1([H])C(C[C@]4(O)C)=O
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Structure Classification
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Initial Source
fungus Bipolaris sp.
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
In Vitro:
Methanol : 4 mg/mL (9.99 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Methanol | 1 mM | 2.4966 mL | 12.4828 mL | 24.9657 mL | 62.4142 mL |
| 5 mM | 0.4993 mL | 2.4966 mL | 4.9931 mL | 12.4828 mL |
Ophiobolin A Related Classifications
HY-N6781 Related Classifications
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