Characterization of 6-epi-3-anhydroophiobolin B from Cochliobolus heterostrophus

  • J Nat Prod. 1999 Jun;62(6):895-7. doi: 10.1021/np980462e.
X Shen  1 ,  S B Krasnoff ,  S W Lu ,  C D Dunbar ,  J O'Neal ,  B G Turgeon ,  O C Yoder ,  D M Gibson ,  M T Hamann
Affiliations
  • 1. Department of Pharmacognosy, National Center for the Development of Natural Products, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
PMID: 10395513 DOI: 10.1021/np980462e
Abstract

The new sesterterpenoid 6-epi-3-anhydroophiobolin B (1) and six known ophiobolins were isolated from the extracts of the fungus Cochliobolus heterostrophus race O. The structure of 6-epi-3-anhydroophiobolin B was deduced from analysis of spectral data and the structural characterization of dehydration and dimerization products. Ophiobolin A (2) showed potent activity in cytotoxicity assays and marginal activity in antimalarial assays.