RARRES1 - retinoic acid receptor responder 1 Gene

Also Known as LXNL; TIG1; PERG-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5918

About RARRES1

Cytogenetic location: 3q25.32 Genomic coordinates (GRCh38): 3:158,696,892-158,732,457 (from NCBI)

This gene has 5 transcripts (splice variants), 118 orthologues and 1 paralogue. Broad expression in appendix (RPKM 33.7), urinary bladder (RPKM 25.5) and 17 other tissues.

Summary

This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate Cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

RARRES1 Products (2)

mRNA Protein Name
NM_002888.4 NP_002879.2 retinoic acid receptor responder protein 1 isoform 2 precursor
NM_206963.2 NP_996846.1 retinoic acid receptor responder protein 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21303978 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RARRES1 Protein Structure

Latexin

Latexin: Latexin (52 - 276)

  • 0
  • 100
  • 200
  • 294 a.a.
Protein Preferred Names Protein Names

retinoic acid receptor responder protein 1

  • RAR-responsive protein TIG1

RARRES1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RARRES1 P49788 SPINK2 Homo sapiens P20155
Anti Bait CoIP
31886233
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurofibroma

  • Neurofibromas

  • Neurofibromatoses

  • Nerve Sheath Tumors
Pinguecula
Conjunctival Degeneration
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11674 RARRES1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RARRES1 RGD RGD:1309509
Bos taurus RARRES1 VGNC VGNC:33731
Canis familiaris RARRES1 VGNC VGNC:45354
Mus musculus RARRES1 MGD MGI:1924461
Macaca mulatta RARRES1 VGNC VGNC:84065
Others RARRES1 NCBI